Evidence map›Paper›PMID 40629579›Full record

ArticleMedicine2025

Association between life's essential 8 and colorectal cancer: A population-based study.

Xiaohan Ma, Xiaofei Zhang, Fasheng Wu, Sheng Chen, Jing Peng, Xuan Lan, Xinyue Zhang, Encun Hou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaohan MaGraduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Xiaofei ZhangRuikang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Fasheng WuRuikang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Sheng ChenGraduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Jing PengGraduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Xuan LanGraduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Xinyue ZhangGraduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Encun HouRuikang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.

Funding

the National Flagship Department of Integrative Medicine (Department of Oncology, Ruikang Hospital, Guangxi University of Traditional Chinese Medicine).
6 · The paper itself

Abstract

Colorectal cancer (CRC) is closely linked to cardiovascular disease. This study investigates the relationship between life's essential 8 (LE8), a recent cardiovascular health metric, and CRC prevalence in US adults. Data from the 2011 to 2018 National Health and Nutrition Examination Survey were used in this study. LE8 was classified into high, moderate, and low levels. The association between LE8 and CRC was assessed using weighted logistic regression, restricted cubic splines, and subgroup analyses. After adjusting for potential confounders, higher LE8 scores were linked to a lower prevalence of CRC. Individuals with the highest LE8 scores had an 81% reduced risk of CRC compared to those with the lowest scores (odds ratio = 0.19; 95% confidence interval: 0.04-0.88, P = .03). Restricted cubic splines analyses revealed a negative correlation between CRC risk and LE8 scores, showing a linear decline as LE8 scores increased (P for non-linearity > .05). LE8 was inversely associated with CRC prevalence in a linear manner. Encouraging adherence to optimal cardiovascular health may help reduce CRC burden.

Indexed as

Colorectal NeoplasmsAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysPrevalenceRisk FactorsUnited Statescolorectal cancerlife’s essential 8risk factorsthe National Health and Nutrition Examination Survey

Identifiers

PMID40629579
PMCPMC12237372

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.