Observational studyMedicine2025
Intraoperative lactate level correlated with the length of hospital stay in patients with intraoperative hypothermia.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to explore potential biomarkers correlated with the clinical outcome only in patients with intraoperative hypothermia undergoing cardiac surgery. The clinical data of patients with or without intraoperative hypothermia, and 8 blood indicators both in preoperative and intraoperative periods, were obtained from the Medical Information Mart for Intensive Care-IV database. The associations of indicators with the length of hospital stay (LOS) were explored in non-hypothermia and hypothermia groups, respectively. The key indicator showing the association only in hypothermia groups was selected for further analysis. The detailed association between the key indicator and LOS was further determined by a series of analyses, including restricted cubic spline, generalized additive model, generalized linear regression, trend regression, threshold effects analysis, and quartile regression. Their clinical value was explored by the receiver operating characteristic analysis and decision curve analysis. Among 16 indicators, only the intraoperative lactate was identified to correlate with the LOS in patients with hypothermia rather than normal group (all P < .05). Lactate showed a positive and nonlinear association with LOS (all P < .05), and their association was especially observed when log-lactate > 2.420 (all P < .05). Quartile regression showed that the associations of lactate with LOS quartiles from 40% and 80% were stably increased when log-lactate > 2.420 (all P < .05). However, no association was observed in any analyses when log-lactate ≤ 2.420. We also confirmed the favorable prediction performance and clinical net benefit of lactate on the LOS. Intraoperative lactate is significantly associated with the LOS of patients with hypothermia and is a useful biomarker.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.