Evidence map›Paper›PMID 40629518›Full record

ArticleThe Journal of infectious diseases2025

Inflammatory Macrophages Associate With Tissue Injury and Fibrosis in a Mouse Model of Tuberculosis.

Julie Boucau, Jennie Ruelas Castillo, Threnesan Naidoo, Yuming Liu, Shatavisha Dasgupta, Neha Jain, Nicholas E Jacobson, Kievershen Nargan, Beth A Cimini, Kevin W Eliceiri and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julie BoucauThe Ragon Institute of Mass General Brigham, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0001-6731-7238
Jennie Ruelas CastilloThe Ragon Institute of Mass General Brigham, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0003-4570-205X
Threnesan NaidooAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0002-1864-4301
Yuming LiuCenter for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Shatavisha DasguptaImaging Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0003-1804-5015
Neha JainThe Ragon Institute of Mass General Brigham, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Nicholas E JacobsonCenter for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kievershen NarganAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Beth A CiminiImaging Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0001-9640-9318
Kevin W EliceiriCenter for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Adrie J C SteynAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Amy K BarczakThe Ragon Institute of Mass General Brigham, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0003-3806-2381

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
Center for Open Bioimage AnalysisP41GM135019 · NIGMS · BROAD INSTITUTE, INC. · PI CARPENTER, ANNE E. · 2020 to 2024
$6.9M
A Global Research Resource for Human TuberculosisR24AI186591 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ADRIE JC STEYN · 2024 to 2026
$3.5M
Elucidating the path to type I IFNs in TB infectionR01AI150762 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BARCZAK, AMY K · 2021 to 2025
$3.2M
Quantitative histopathology for cancer prognosis using quantitative phase imaging on stained tissuesR01CA238191 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ANASTASIO, MARK A, ELICEIRI, KEVIN WILLIAM · 2019 to 2023
$3.1M
METABOLIC REPROGRAMMING OF T CELL ENERGY METABOLISM IN TUBERCULOSIS AND HIVR33AI138280 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2020 to 2023
$2.0M
Targeting MT1-MMP to inhibit pathologic inflammation in TBR21AI146813 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BARCZAK, AMY K · 2019 to 2020
$418k
NCI NIH HHS R01 CA238191NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI150762NIAID NIH HHS R21 AI146813NIAID NIH HHS R24 AI186591NIAID NIH HHS R33 AI138280NIBIB NIH HHS P41 EB031772NIGMS NIH HHS P41 GM135019NIH HHS P41GM135019NIH HHS R01CA238191NIH HHS R21AI146813NIH HHS R24AI186591NIH HHS R33AI138280Ragon InstituteWellcome LeapWellcome Trust
6 · The paper itself

Abstract

backgroundPost-tuberculosis lung disease causes a significant burden of global disease. While a consensus definition of post-tuberculosis lung disease is still in development, parenchymal cavitation, bronchiectasis, and fibrosis are recognized pathologic features. The molecular mechanisms driving development of each feature are largely unknown.

methodsTo facilitate the mechanistic study of tuberculosis-associated pathologic tissue remodeling and fibrosis, we adapted a mouse model of infection.

resultsThe morphologies of fibrosis observed in mice were similar to those observed in human tissue samples, and fibrillar collagen deposition did not resolve with antituberculosis antibiotics. Inflammatory transcriptional signatures were persistently upregulated during chronic infection and did not fully resolve after weeks of antibiotics. Inflammatory and fibrosis-associated macrophages similarly persisted during treatment. Immunofluorescence microscopy revealed persistent macrophage populations and shifts in abundance and distribution of type 2 alveolar cells at sites of fibrogenesis.

conclusionsA mouse model recapitulates key aspects of tuberculosis-assocaiated fibrosis. Transcriptional and cellular markers of inflammation persist through weeks of antibiotic treatment.

Indexed as

MacrophagesPulmonary FibrosisTuberculosis, PulmonaryAnimalsDisease Models, AnimalFemaleFibrosisHumansInflammationLungMiceMice, Inbred C57BLfibrogenesisfibrosishost-pathogenmacrophagemycobacteriatissue injurytuberculosis

Identifiers

PMID40629518
PMCPMC12718066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.