ArticleEuropean journal of medical research2025
ERCC1/NGFR affects prognosis in basal-like breast cancer.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
objectivesTo study the effects of ERCC1 and NGFR on metastasis and prognosis of basal-like breast cancer, and construct a prognostic prediction model, initially to explore whether ERCC1 plays a role in BLBC metastasis through NGFR.
methodsRNA-seq was used to identify the metastasis-related gene NGFR associated with ERCC1. ERCC1 and NGFR were transfected into BLBC cells, then western blot and transwell assays were applied to explore the effects of ERCC1 and NGFR on the migratory/invasive abilities and whether ERCC1 plays a role in BLBC cell metastasis through the NGFR. Data from the TCGA database were used to analyze the relationship between NGFR and ERCC1 expression in BLBC patients. The effects of ERCC1 and NGFR on the prognosis were analysed using K-M survival curves and multifactorial Cox regression, and a prognostic prediction model was constructed.
resultsRNA-seq results showed that NGFR was a differentially expressed gene of ERCC1, and NGFR was associated with ERCC1.After knockdown of ERCC1, the migratory and invasive abilities of cancer cells were significantly reduced; after overexpression of NGFR, the migratory and invasive abilities of cancer cells were significantly enhanced. In ERCC1 knockdown cancer cells, the expression levels of NGFR were subsequently reduced, and overexpression of NGFR resulted in an increase in migrating and invading cells and a rebound in migration and invasion capacity. NGFR was positively correlated with ERCC1 expression levels in BLBC patients (r
conclusionsA positive correlation was observed between ERCC1 and NGFR. ERCC1 may affect the migration and invasion ability of BLBC cells through NGFR; ERCC1 and NGFR were independent risk factors for the poor prognosis of BLBC patients and had a predictive effect on the 3-year and 5-year prognosis of BLBC.
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