Evidence map›Paper›PMID 40629294›Full record

ArticleBMC geriatrics2025

Protocol for the REBOUND study: a cohort study to uncover fundamental mechanisms of accelerated ageing and impaired resilience following cancer surgery and treatment.

Carly Welch, Animesh Acharjee, Rebecca Birch, João Pedro de Magalhães, Niharika A Duggal, Alison Hainsworth, Jose R Hombrebueno, Simon W Jones, Jonathan Lewis, Ali Mazaheri and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Carly WelchDepartment of Twin Research & Genetic Epidemiology, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, 3rd Floor South Wing D Block, St Thomas' Campus, Westminster Bridge, London, SE17EH, UK. carly.welch@kcl.ac.uk.
Animesh AcharjeeDepartment of Cancer and Genomic Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Rebecca BirchDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
João Pedro de MagalhãesDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Niharika A DuggalDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Alison HainsworthDepartment of Colorectal Surgery, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, 12th Floor, Westminster Bridge, London, SE17EH, UK.
Jose R HombrebuenoDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Simon W JonesDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Jonathan LewisDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Ali MazaheriSchool of Psychology, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Helen M McGettrickDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Thomas NicholsonDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Judith PartridgeDepartment of Twin Research & Genetic Epidemiology, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, 3rd Floor South Wing D Block, St Thomas' Campus, Westminster Bridge, London, SE17EH, UK.
Thomas PinkneyDepartment of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Claire J StevesDepartment of Twin Research & Genetic Epidemiology, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, 3rd Floor South Wing D Block, St Thomas' Campus, Westminster Bridge, London, SE17EH, UK.
Kristina TomkovaDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Daisy WilsonDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Thomas A JacksonDepartment of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAgeing is a heterogeneous process, which is associated with heterogeneous resilience in older people. Cancer surgery and treatment may be associated with accelerated ageing in some older people; studying this process will improve understanding to enable treatments to prevent adverse effects on physical and cognitive function.

methodsThis study will recruit 172 participants aged 65 years and older scheduled to undergo elective colorectal surgery for cancer from two hospital sites (Guy's and St Thomas' NHS Foundation Trust and University Hospitals Birmingham NHS Foundation Trust). Assessments will be performed preoperatively, days 1-3 postoperatively, 30 days postoperatively, and 90 days postoperatively. These will include in-depth clinical phenotyping including handgrip strength, Short Physical Performance Battery, muscle ultrasound, cognitive tests, Electroencephalography, questionnaires including quality of life, and physical activity using remote devices. Serial blood and stool specimens will be collected across timepoints to measure underlying hallmarks of ageing including inflammation, dysbiosis, macroautophagy, cellular senescence, epigenetic alterations, mitochondrial dysfunction, and stem cell exhaustion. A machine learning approach will be utilised to evaluate the associations between trajectories in clinical and physiological parameters and fundamental biological processes. DISCUSSION: This study represents an exciting collaboration between clinicians, fundamental scientists, and experts in machine learning. It offers the opportunity to characterise and understand complex pathways to enable future clinical trials directed towards the prevention of accelerated ageing through a stratified medicine approach.

Indexed as

AgingColorectal NeoplasmsNeoplasmsResilience, PsychologicalAgedAged, 80 and overCohort StudiesFemaleHumansMaleQuality of LifeDeliriumFrailtySarcopeniaSenescenceStratified medicine

Identifiers

PMID40629294
PMCPMC12235963

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.