The Complicity of DAAM1, PTMA, RSPH6A, and Steroidogenic Genes in the Fertility of Male Rats Exposed to Cadmium During Gestation and Lactation: Attenuation by PREOG.

Ikokide Emmanuel Joseph, Jaja Ishmael Festus, Temitayo Olabisi Ajibade, Ademola Adetokunbo Oyagbemi, Mathew Olugbenga Oyeyemi

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Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Ikokide Emmanuel JosephDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Jaja Ishmael FestusDepartment of Livestock and Pasture Science, University of Fort Hare, Alice, 5700, South Africa. ijaja@ufh.ac.za.

Temitayo Olabisi AjibadeDepartment of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Ademola Adetokunbo OyagbemiDepartment of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Mathew Olugbenga OyeyemiDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Funding

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6 · The paper itself

Abstract

The role of cadmium in the dwindling male fertility rate in men and animals has been extensively documented in several studies over the years, and various natural compounds have been used to successfully manage it. In this study, we investigated the impact of exposing dams to polyphenol-rich extract of Ocimum gratissimum (PREOG)/cadmium during gestation and lactation on the reproductive outcome in adult male offspring (PND 90). Sixty adult females were randomly assigned to groups A-F (n = 10) and cohabitated with adult males in a ratio of 2:1 for ten days. At day 7, each female received oral treatment daily as follows; A (served as the control), B (received 3 mg/kg CdCL

Indexed as

CadmiumFertilityLactationPlant ExtractsPrenatal Exposure Delayed EffectsAnimalsFemaleMalePregnancyRatsRats, WistarTestisCadmiumPlant ExtractsCadmiumDAAM1PREOGPTMA. RSPH6Aq-RT-PCRSteroidogenesis

Identifiers

PMID40629240

DOI10.1007/s43032-025-01902-x

PMCPMC12361343

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.