Evidence map›Paper›PMID 40629217›Full record

ArticleThe European journal of health economics : HEPAC : health economics in prevention and care2026

Health economic outcomes and national economic impacts associated with Long COVID in England and Scotland.

Joseph Kwon, Joseph Mensah, Ruairidh Milne, Clare Rayner, Román Rocha Lawrence, Johannes De Kock, Manoj Sivan, Stavros Petrou, LOCOMOTION consortium

Abstract read
In one paragraph

Article in The European journal of health economics : HEPAC : health economics in prevention and care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joseph KwonNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, United Kingdom. joseph.kwon@phc.ox.ac.uk.ORCID http://orcid.org/0000-0002-2860-7280
Joseph MensahSheffield Centre for Health and Related Research, University of Sheffield, Sheffield, England, United Kingdom.ORCID http://orcid.org/0009-0001-7664-8458
Ruairidh MilneSchool of Healthcare Enterprise and Innovation, University of Southampton, Southampton, England, United Kingdom.ORCID http://orcid.org/0000-0002-5117-4380
Clare RaynerLOCOMOTION Patient Advisory Group Co-Lead, University of Leeds, Sheffield, England, United Kingdom.ORCID http://orcid.org/0000-0002-5167-6903
Román Rocha Lawrence, ELAROS 24/7 Ltd, Sheffield, England, United Kingdom.ORCID http://orcid.org/0000-0002-1913-9825
Johannes De KockCOVID Recovery Service, NHS Highland, Inverness, Scotland, United Kingdom.ORCID http://orcid.org/0000-0002-2468-5572
Manoj SivanLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England, United Kingdom.ORCID http://orcid.org/0000-0002-0334-2968
Stavros PetrouNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, United Kingdom.ORCID http://orcid.org/0000-0003-3121-6050
LOCOMOTION consortium

Funding

National Institute for Health and Care Research COV-LT2-0016
6 · The paper itself

Abstract

backgroundTwo million people in the UK suffer from Long COVID (LC), imposing substantial health economic impacts. This study aimed to: 1) assess longitudinal changes in health utility scores and economic costs of LC, and number of services received at LC specialist clinics and clinic region to capture care intensity; 2) assess whether volume of services received responded to health needs; and 3) estimate the national economic impact of LC.

methodsLC patients from 10 specialist clinics participated in the LOCOMOTION study. Patient-reported outcomes measures (EQ-5D-5L, C19-YRS and Health Economics Questionnaire) were completed on a digital platform. Associations were assessed between changes in economic outcomes (EQ-5D-3L utility, health economic costs) and number/type of LC specialist services received and region. Per-person values of quality-adjusted life-year losses, public sector costs, productivity losses and informal care costs were multiplied by LC prevalence to estimate national economic impacts.

resultsThere was a statistically significant reduction in public sector costs over time. There was no significant association between the number of specialist services received and change in health utility scores. LC specialist clinic and outpatient service utilisation corresponded to health need and had significant regional variation after controlling for health need. LC is associated with a substantial economic impact nationally, estimated at £8.1 billion annually and £24.2 billion since its emergence, comparable to the annual cost of £9.4 billion for stroke.

conclusionThe effectiveness of LC specialist clinic services warrants further research. The substantial national economic impact of LC warrants a nationwide LC care strategy.

Indexed as

COVID-19Health Care CostsAdultAgedCost of IllnessEnglandFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresPost-Acute COVID-19 SyndromeQuality-Adjusted Life YearsSARS-CoV-2ScotlandHealthcare utilisationHealth utilityInformal caregivingLong COVIDProductivity

Identifiers

PMID40629217
PMCPMC12929292

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.