Evidence map›Paper›PMID 40629189›Full record

ArticleArchives of toxicology2025

A simplified LC-MS-based method for sensitive analysis of DNA adducts utilizing accessible in vitro metabolism models.

Andrea Gerdemann, Matthias Behrens, Georgia Günther, Ahmed Ghallab, Jan G Hengstler, Hans-Ulrich Humpf, Melanie Esselen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea GerdemannInstitute of Food Chemistry, University of Münster, Corrensstraße 45, 48149, Münster, Germany. andrea.gerdemann@uni-muenster.de.ORCID 0009-0005-3617-0700
Matthias BehrensInstitute of Food Chemistry, University of Münster, Corrensstraße 45, 48149, Münster, Germany.ORCID 0000-0001-5425-8144
Georgia GüntherLeibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany.
Ahmed GhallabLeibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany.ORCID 0000-0003-0695-3403
Jan G HengstlerLeibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany.ORCID 0000-0002-1427-5246
Hans-Ulrich HumpfInstitute of Food Chemistry, University of Münster, Corrensstraße 45, 48149, Münster, Germany.ORCID 0000-0003-3296-3058
Melanie EsselenInstitute of Food Chemistry, University of Münster, Corrensstraße 45, 48149, Münster, Germany.ORCID 0000-0002-7590-6179

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic information of living cells is encoded by the specific arrangement of nucleobases in deoxyribonucleic acid (DNA). Even minor changes or modifications of these nucleobases, favored by many reactive sites, can significantly affect correct replication and DNA integrity leading to severe toxic effects. Analyzing these DNA modifications is highly complex and often requires non-specific assays for DNA damage or

Indexed as

CarcinogensDNA AdductsAnimalsChromatography, High Pressure LiquidChromatography, LiquidHepatocytesHep G2 CellsHumansLiquid Chromatography-Mass SpectrometryMass SpectrometryCarcinogensDNA Adducts3-MonochloropropanediolAflatoxin B1Alpha-asarone and beta-asaroneBenzo[a]pyreneHepG2 cellsLiver S9 fractionMethyleugenolPrimary hepatocytes

Identifiers

PMID40629189
PMCPMC12454591

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.