ArticleCurrent microbiology2025
Anti-Bacterial Activity of Furan Chalcone Derivatives Against Mycobacterium tuberculosis: Design, Synthesis, Anti-Bacterial Screening, Pharmacokinetic Properties, and Toxicity Parameters.
Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Exploration of a Novel Thiadiazole Derivative: Design, Synthesis, Biological Evaluation (In Vitro and in Silico), and DFT Studies.Journal of fluorescence · 2026Article
- Antibiotic-phytochemical combinations against Enterococcus faecalis: a therapeutic strategy optimized using response surface methodology.Antonie van Leeuwenhoek · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel series of fifty furan-based chalcone derivatives and their potential anti-bacterial activity against Mycobacterium tuberculosis was studied in this present work. The pharmacokinetic properties and toxicity parameters of these designed molecules were studied using in silico methods. Physicochemical parameters were computed for all the designed molecules and Swiss ADME analysis demonstrated that the designed compounds possess good drug-like properties. Among them top 10 compounds were selected based on initial ADME screening and subjected to docking investigations using the Autodock Tool. 1.5.6. The binding energies and interactions of these compounds with the target protein InhA were compared with established anti-tubercular medicines (isoniazid and ethionamide). Based on docking results, the top furan chalcones were synthesized and analyzed using various spectroscopic techniques such as FT-IR, mass spectrometry,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.