ArticleJournal of cancer research and clinical oncology2025
Analysis of clinicopathologic characteristics and risk factors for missed diagnosis in synchronous multiple early gastric cancer.
Article in Journal of cancer research and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Therapeutic Potential of Polysaccharide-Modulated Gut Microbiota-Immune Axis in Gastrointestinal Cancers: Modern Insights From Traditional Pharmacy.Molecular nutrition & food research · 2026Review
- Metachronous multifocal early gastric cancer after partial gastrectomy for synchronous multifocal early gastric cancer: a case report and literature review.Frontiers in medicine · 2026Article
- Overcoming diagnostic pitfalls in primary gastric squamous cell carcinoma: the imperative of adequate sampling in an elderly female patient, case report.Frontiers in oncology · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
aimsThis study aimed to enhance synchronous multiple early gastric cancer (SMEGC) detection by analyzing clinicopathological features, correlations between main/minor lesions in SMEGC and gastric high-grade intraepithelial neoplasia (GHGIN), and identifying risk factors for missed diagnoses.
methodA cross-sectional analysis included 130 patients with SMEGC or GHGIN undergoing endoscopic submucosal dissection (ESD) at Nanjing Drum Tower Hospital. Clinicopathological characteristics were evaluated, with lesions classified as main or minor. Correlations between lesions were assessed based on size, location, endoscopic morphology, histopathology, invasion depth, and vascular invasion. Risk factors for missed diagnoses were analyzed.
resultsOf 2580 patients treated with ESD, 130 with SMEGC or GHGIN were included in this study. The sizes of the main and minor lesions were positively correlated (r = 0.658, p < 0.001). The main and minor lesions showed moderate consistency in pathological type (kappa = 0.421, p < 0.001) and low consistency in endoscopic morphology, depth of invasion, and longitudinal position (kappa < 0.4, p < 0.05). Of 130 included patients, diagnoses for 37 were missed. Small and non-primary lesions were independent risk factors for missed lesions. We also found that the hospital grade at first gastroscopy was a risk factor for missed diagnosis.
conclusionsEndoscopists should be aware of the risk factors associated with SMEGC and consider the correlation between the main and minor lesions to prevent the oversight and misdiagnosis of SMEGC.
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