ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025
Assessment of T2-weighted MRI-derived synthetic CT for the detection of suspected lumbar facet arthritis: a comparative analysis with conventional CT.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
purposeWe evaluated sCT generated from T2-weighted imaging (T2WI) using deep learning techniques to detect structural lesions in lumbar facet arthritis, with conventional CT as the reference standard.
methodsThis single-center retrospective study included 40 patients who had lumbar MRI and CT with in 1 week (September 2020 to August 2021). A Pix2Pix-GAN framework generated CT images from MRI data, and image quality was assessed using structural similarity index (SSIM), mean absolute error (MAE), peak signal-to-noise ratio (PSNR), nd Dice similarity coefficient (DSC). Two senior radiologists evaluated 15 anatomical landmarks. Sensitivity, specificity, and accuracy for detecting bone erosion, osteosclerosis, and joint space alterations were analyzed for sCT, T2-weighted MRI, and conventional CT.
resultsForty participants (21 men, 19 women) were enrolled, with a mean age of 39 ± 16.9 years. sCT showed strong agreement with conventional CT, with SSIM values of 0.888 for axial and 0.889 for sagittal views. PSNR and MAE values were 24.56 dB and 0.031 for axial and 23.75 dB and 0.038 for sagittal views, respectively. DSC values were 0.935 for axial and 0.876 for sagittal views. sCT showed excellent intra- and inter-reader reliability intraclass correlation coefficients (0.953-0.995 and 0.839-0.983, respectively). sCT had higher sensitivity (57.9% vs. 5.3%), specificity (98.8% vs. 84.6%), and accuracy (93.0% vs. 73.3%) for bone erosion than T2-weighted MRI and outperformed it for osteosclerosis and joint space changes.
conclusionssCT outperformed conventional T2-weighted MRI in detecting structural lesions indicative of lumbar facet arthritis, with conventional CT as the reference standard.
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