Evidence map›Paper›PMID 40629158›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

An exploration of the relationship between perceived injustice and pain severity in breast cancer survivors: a structural equation model.

Eva Roose, Wouter Van Bogaert, Kenza Mostaqim, Eva Huysmans, Jo Nijs, C Paul van Wilgen, David Beckwée, Annick Timmermans, Christel Fontaine, Astrid Lahousse

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04730154 (The Effect of Perceived Injustice Targeted Pain Neuroscience Education and Motivational Interviewing Compared to Biomedical Focused Education in Breast Cancer Survivors), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04730154 naactive not recruitingnot on this map

The Effect of Perceived Injustice Targeted Pain Neuroscience Education and Motivational Interviewing Compared to Biomedical Focused Education in Breast Cancer Survivors

TypeinterventionalSponsorUniversitair Ziekenhuis BrusselRan2021 to 2026Enrolled156ConditionsBreast Neoplasms, Survivorship, Pain, ChronicArmsPain Neuroscience Education (PNE), Motivational Interviewing (MI), Biomedically-focused education
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eva RoosePain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium. eva.charlotte.s.roose@vub.be.ORCID http://orcid.org/0000-0001-8720-6543
Wouter Van BogaertPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0003-3761-0497
Kenza MostaqimPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0002-9962-1311
Eva HuysmansPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0002-2571-6967
Jo NijsPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0002-4976-6563
C Paul van WilgenPain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0001-6748-6947
David BeckwéeRehabilitation Research Group, Department of Physiotherapy, Vrije Universiteit Brussel, Vrije Universiteit Brussel (KIMA), Laarbeeklaan 103, 1090, Brussels, Belgium.ORCID http://orcid.org/0000-0001-9951-9993
Annick TimmermansREVAL, Universiteit Hasselt, Agoralaan-Gebouw A, 3590, Diepenbeek, Belgium.ORCID http://orcid.org/0000-0002-5461-947X
Christel FontaineMedical Oncology Department, University Hospital Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium.ORCID http://orcid.org/0000-0002-4524-5744
Astrid LahoussePain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0003-3967-8348

Funding

Kom op tegen Kanker ANI251
6 · The paper itself

Abstract

purposeThe construct of perceived injustice is receiving increased attention in pain research due to its relationship with adverse pain outcomes. Even though cancer survivors face a 30% risk of developing pain, there is a notable lack of research exploring this relationship within this population. Therefore, this study aims to explore the relationship of perceived injustice with pain severity in breast cancer survivors (BCS).

methodsA directed acyclic graph (DAG) (i.e., path model) was multidisciplinary created a priori, positioning perceived injustice -measured with the Injustice Experienced Questionnaire (IEQ)- as the main exposure variable and pain severity -measured with the Brief Pain Inventory (BPI)- as the main outcome variable, with the addition of explanatory variables within the relationship of IEQ and BPI. Data from 156 female BCS with pain and perceived injustice were analysed using structural equation modelling, with confidence intervals estimated through Montecarlo simulation.

resultsPerceived injustice did not have a significant univariate direct relationship with pain severity (β = 0.186, p = 0.102). However, in the complete path model including explanatory outcomes, a significant relationship was observed (β = 0.304, 95% CI [0.136; 0.477]), explaining 22,5% of the variance in pain severity. In the complete model, the greatest proportion of the effect was mediated through pain catastrophizing (β = 0.226, 95% CI [0.101; 0.376]).

conclusionThe findings indicate that perceived injustice has an important relationship with pain severity levels of BCS experiencing pain and perceived injustice. Multimodal intervention studies are suggested for future investigation as a treatment for pain in BCS. REGISTRATION PRIOR TO RECRUITMENT AT: ClinicalTrials.gov NCT04730154.

Indexed as

Breast NeoplasmsCancer PainCancer SurvivorsAdultAgedFemaleHumansLatent Class AnalysisMiddle AgedPain MeasurementSeverity of Illness IndexSurveys and QuestionnairesOncologyPainPain catastrophizingPerceived injusticeSurvivorship

Identifiers

PMID40629158

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.