ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Microglia as critical mediators linking perinatal immune stress to mental health trajectories.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Research Progress on Bidirectional Regulation of the Microbiota-Gut-Brain Axis in Autism Spectrum Disorder Based on the Immune-Metabolic-Endocrine Interactive Network.Biomolecules · 2026Review
- Not just neurons: glial mechanisms driving sex-specific vulnerability to withdrawal and relapse in substance use disorder.Frontiers in neuroendocrinology · 2026Review
- Immunometabolic reprogramming of central and peripheral immune cells in mental disorders: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Trajectories of mental health and mental illness: where we are now and where we go next.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Modeling Pain Without Injury: Inherited Rodent Models as Mechanistic Windows into Chronic Pain.Function (Oxford, England) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Neurodevelopmental and neuropsychiatric disorders that emerge in childhood (such as autism) and adolescence (such as depression and schizophrenia) currently lack broadly effective therapies, underlying an urgent need to better understand their etiology. While each disorder has its own set of complex genetic and environmental risk factors, perinatal exposure to intense immune activation and/or stress has been linked to increased disease risk. Microglia, the resident immune cells of the brain, are impacted in each disorder and exquisitely sensitive to early life experience. Here, we review the literature suggesting microglia-specific changes in response to early life immune activation and/or stress with an emphasis on microglial interactions with neural synapses and circuits. We also review the existing literature linking these findings to microglia-specific changes in the brain in autism, depression, and schizophrenia. Our goal is to bridge the gap between developmental insults and the subsequent pathogenesis of these disorders, highlighting key areas for future mechanistic work.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.