Evidence map›Paper›PMID 40628992›Full record

ArticleNPJ digital medicine2025

Effects of intervention design on engagement and outcomes in digital self-help for insomnia - factorial RCT.

Amira Hentati, Nils Hentati Isacsson, Ann Rosén, Susanna Jernelöv, Viktor Kaldo, Brjánn Ljótsson, Erik Forsell, Nils Lindefors, Martin Kraepelien

Registry-linked trialAbstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05826002 (Optimization of a Digital Self-guided Psychological Intervention for Insomnia), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05826002 nacompletednot on this map

Optimization of a Digital Self-guided Psychological Intervention for Insomnia: A Randomized Factorial Experiment

TypeinterventionalSponsorKarolinska InstitutetRan2023 to 2024Enrolled447ConditionsInsomniaArmsDigital self-guided psychological intervention for insomnia
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amira HentatiCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. amira.hentati@ki.se.
Nils Hentati IsacssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Ann RosénCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Susanna JernelövCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Viktor KaldoCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Brjánn LjótssonDivision of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Erik ForsellCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Nils LindeforsCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Martin KraepelienCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Digital self-help can improve access to mental health care, but poor engagement limits effectiveness. This single-blind 2 x 2 x 2 factorial randomized controlled trial examined whether an optimized graphical user interface (GUI), automated reminders (AR), and an adaptive treatment strategy (ATS) improved engagement and outcomes in a digital self-help insomnia intervention. Adults (N = 447) with moderate to severe insomnia were randomized to combinations of the factors. The GUI improved self-rated engagement, sleep log activity, login frequency, and usability. AR increased sleep log activity and logins, while ATS improved satisfaction. All three combined significantly improved insomnia symptoms (d = 0.50). No severe adverse effects were reported. Clinicians spent 13.74 min on average on the ATS. Statistical analyses included linear and multilevel regression. Factors were effect coded. Intervention design can enhance engagement and outcomes, requiring minimal clinician time. Pre-registered 2023-04-11 (ClinicalTrials.gov, NCT05826002). Funded by the Swedish Ministry of Health and Social Affairs, grant number: S2018/03855/FS.

Identifiers

PMID40628992
PMCPMC12238518

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.