ArticleScientific reports2025
IMRC-exo alleviates limb injury by inhibiting ferroptosis in a rabbit model of deinagkistrodon acutus snakebite envenomation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Role of Regulated Cell Death Pathways in Snakebite Envenomation: Mechanisms, Crosstalk, and Therapeutic Opportunities.International journal of molecular sciences · 2026Review
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9 authors.
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Abstract
Deinagkistrodon acutus is one of the unique venomous snakes native to Southeast Asia. Limb injury caused by this species is the main cause of disability in snake bite patients, while the relevant pathogenesis mechanism and intervention strategies need to be further explored. In recent years, studies have established that mesenchymal stem cell-derived exosome (MSC-Exo) exerts a positive therapeutic effect on reducing limb injuries caused by a variety of factors, but this effect in limb injuries caused by snake bite is still unclear. Immunity-and-matrix regulatory cell (IMRC) is a type of mesenchymal stem cell derived from human embryonic stem cells, characterized by its unique capabilities in immune regulation and regulation of extracellular matrix production. In this study, IMRC was selected to investigate the effects and mechanisms of its Exo on limb injury induced by Deinagkistrodon acutus venom. Eighteen healthy male white rabbits were divided into Sham (S) group, Snake venom (SV) group and SV + IMRC-Exo group according to a random number table, with 6 rabbits in each group. Rabbit models of snakebite were established by limb injection of 1.5 mg/kg snake venom, followed by intravenous injection of 80 U/kg antivenom 2 h later. Additionally, subcutaneous injection of 7.5 × 10
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