Evidence map›Paper›PMID 40628971›Full record

ArticleScientific reports2025

Centrifuge-free cell radiolabeling using acoustophoresis.

Stephen S Adler, Emma Stevenson, Julia Alsveds, Peter L Choyke, Noriko Sato

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephen S AdlerClincal Research Directorate, Frederick National Laboratory for Cancer Research, Fredrick, MD, USA. stephen.adler@nih.gov.
Emma StevensonUniversity of Alabama at Birmingham, Birmingham, USA.
Julia AlsvedsAcouSort AB, Lund, Sweden.
Peter L ChoykeNational Cancer Institute, Bethesda, MD, USA.
Noriko SatoNational Cancer Institute, Bethesda, MD, USA.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NCI NIH HHS 75N91019D00024NCI NIH HHS Contract No. 75N91019D00024NCI NIH HHS Intramural Program
6 · The paper itself

Abstract

Tracking ex vivo radiolabeled cells using radionuclide imaging such as positron emission tomography is an emerging method for evaluating cell-based therapies. Traditional radiolabeling requires a centrifuge in multiple steps to optimize labeling and remove unbound radiotracers. With the goal of automating the radiolabeling procedure, we explored an acoustophoresis-based approach for radiolabeling cells, eliminating the need of using a centrifuge, simplifying the design of this future device. The AcouWash 2 (AcouSort AB, Lund, Sweden), an acoustophoresis based cell washing device, was evaluated for its ability to label EL4 murine T lymphoblasts with zirconium-89 (

Indexed as

Cell TrackingIsotope LabelingAnimalsCentrifugationMiceOxyquinolineRadioisotopesZirconiumOxyquinolineRadioisotopesZirconiumZirconium-8989Zr-oxineAcoustophoresisCell radiolabelingCell up-concentrationCell washing

Identifiers

PMID40628971
PMCPMC12238631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.