ArticleCommunications biology2025
PP2Acα regulates sleep amount and sleep homeostasis in mice.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Genetic studies in mice have identified multiple sleep-regulating protein kinases, but the sleep functions of protein phosphatases remain largely unclear. Here, we performed adeno-associated virus-mediated somatic genetics analysis of PP2A catalytic subunits-PP2Acα and PP2Acβ-in sleep regulation in male mice. Adult brain chimeric (ABC) knockout of PP2Acα, but not PP2Acβ, across mouse brain neurons reduces daily amount of rapid eye movement (REM) and non-REM (NREM) sleep, but elevates NREM delta power. Additionally, ABC-PP2Acα
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