ArticleScientific reports2025
Intrapleural injection of bupivacaine liposome for pain management after thoracoscopic surgery.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Comparison of Liposomal Bupivacaine for Single-Injection Versus Dual-Injection Thoracic Paravertebral Block on Analgesic Effect After Dual-Microport Thoracoscopic Lobectomy: A Prospective Randomized Controlled Trial.Pain research & management · 2026Trial
- Liposomal Bupivacaine versus Bupivacaine with Dexamethasone for Rhomboid Intercostal and Sub-Serratus Block in Thoracoscopic Lobectomy: A Randomized Controlled Trial.Journal of pain research · 2026Trial
- Integrated drainage-analgesia in thoracoscopic surgery: cautionary optimism amidst evolving multimodal guidelines.Journal of thoracic disease · 2026Article
- Targeted intrapleural analgesia through an integrated chest tube after thoracoscopic lung resection: a randomized controlled trial.Journal of thoracic disease · 2026Article
- Liposomal bupivacaine in thoracic surgery: a comprehensive review of current evidence and clinical implications.Frontiers in medicine · 2026Review
- The impact of liposomal bupivacaine erector spinae plane block on postoperative analgesia and early functional recovery in patients undergoing thoracoscopic lung cancer surgery.Frontiers in oncology · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Thoracoscopic minimally invasive surgery is widely recognized for its efficacy in pain management. Nevertheless, postoperative pain control continues to pose a significant challenge in thoracic surgery. The objective of this study was to investigate the impact of bupivacaine liposomes on postoperative pain management in patients undergoing thoracoscopic lung surgery. All patients who underwent thoracoscopic surgery between March 2024 and October 2024 were retrospectively analyzed. In the patient controlled intravenous analgesia (PCIA) group, a total of 171 patients received thoracoscopic pneumonectomy without intrapleural intercostal nerve block (INB). Conversely, in the bupivacaine liposome (BL) group, another set of 171 patients underwent thoracoscopic minimally invasive surgery with intrapleural intercostal nerve infiltration anesthesia. Pain scores, measured using the Numerical Rating Scale (NRS), were recorded on the day following surgery as well as on days 1, 2, and 3 postoperatively or at the time of discharge. Additionally, we documented both postoperative analgesic consumption and any temporary emergency analgesics administered. Length of stay (LOS) and occurrences of postoperative arrhythmia were compared between the two groups. Among 342 patients undergoing thoracoscopic minimally invasive lung surgery, the LOS in the BL group was nearly half a day shorter (12.24 h) compared to the PCIA group. The consumption of postoperative analgesics in the BL group was significantly lower than that observed in the PCIA group (P = 0.038). Additionally, there were more instances of rescue analgesic use in the PCIA group than in the BL group. In patients undergoing thoracoscopic lung surgery, the administration of intrapleural intercostal nerve block utilizing bupivacaine liposome can alleviate postoperative pain and reduce the need for analgesics following the procedure. This method represents a safe adjunctive treatment for the pain management of postoperative pulmonary surgery.
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