ArticleScientific reports2025
Structural and functional effects of helix dipole moment in photoprotein Mnemiopsin 2.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Here, we designed and constructed a double mutant of photoprotein Mnemiopsin 2 by targeting two antiparallel helix fragments within the structure of photoprotein. In designing of the mutation, two helices were treated as electric dipoles, and their dipole character was manipulated by substituting neutral residues with charged ones at the helix termini. Activity measurements have revealed that mutant protein exhibits a higher initial luminescence intensity compared to the wild-type photoprotein. Based on the intrinsic and extrinsic fluorescence measurements, the overall tertiary structure of mutant photoprotein becomes more compact than the wild-type photoprotein. Heat-induced unfolding experiments demonstrated that the mutant photoprotein exhibited a 3
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