Evidence map›Paper›PMID 40628923›Full record

Observational studyScientific reports2025

Contemporary outcomes in no-option chronic limb-threatening ischemia.

Anahita Dua, Richard J Powell, Arthur C Lee, Nelson Bernardo, Joseph L Mills, Lucas Ferrer Cardona, Matthew C Bunte, Jorge L Martínez-Trabal, Samir Ghandour, Sagar S Gandhi and 4 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Superficial venous arterialization outflow stenting, an alternative to open venous branch ligation.Journal of vascular surgery cases and innovative techniques · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anahita DuaDivision of Vascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. adua1@mgh.harvard.edu.
Richard J PowellDivision of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Arthur C LeeHCA Florida North Florida Hospital, The Cardiac and Vascular Institute, Gainesville, FL, USA.
Nelson BernardoDepartment of Cardiology, MedStar Georgetown University, Washington, DC, USA.
Joseph L MillsDivision of Vascular Surgery and Endovascular Therapy, The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Lucas Ferrer CardonaDivision of Vascular Surgery, Dell Seton Medical Center, University of Texas at Austin, Austin, TX, USA.
Matthew C BunteSaint Luke's Mid America Heart Institute, Kansas City, MO, USA.
Jorge L Martínez-TrabalThe Division of Vascular Surgery, Ponce Health Sciences University, St. Luke's Episcopal Hospital, Ponce, Puerto Rico.
Samir GhandourDivision of Vascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sagar S GandhiDivision of Vascular Surgery, Prisma Health Upstate, Greenville, SC, USA.
Zola N'DanduFormerly Department of Cardiology, Ochsner Medical Center, New Orleans, LA, USA.
Peter A SchneiderThe Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, USA.
Daniel ClairDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Mehdi H ShishehborUniversity Hospitals Harrington Heart and Vascular Institute, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of chronic limb-threatening ischemia, the most severe form of peripheral artery disease, is increasing. A considerable portion are deemed "no-option" patients and have high rates of limb loss and death, with even worse outcomes in underrepresented populations. This study aimed to delineate real-world, contemporary outcomes in an observational study of no-option chronic limb-threatening ischemia patients. The composite primary end point was amputation-free survival (defined as freedom from death and above-ankle amputation) at 1 year. A total of 180 patients with no-option chronic limb-threatening ischemia were included from 22 centers across the US. The median age was 70 years (IQR, 61-78 years), 33% were women, 39% were Black, and 11% were Hispanic/Latino. Comorbidities included 76% with diabetes, 33% with heart failure, and 25% with end-stage renal disease. At 1 year, the amputation-free survival rate was 37%, 45% had major amputation, and 33% died. Additionally, two-thirds of the remaining patients had persistent non-healing ulcers, 44% had minor amputation, and 83% required ambulatory assistance. In this severely diseased population, approximately half of patients underwent major amputation and one-third died within a year, highlighting the pressing need for innovative interventions for limb salvage.

Indexed as

Amputation, SurgicalChronic Limb-Threatening IschemiaIschemiaLimb SalvagePeripheral Arterial DiseaseAgedFemaleHumansMaleMiddle AgedTreatment OutcomeAmputationChronic limb-threatening ischemiaLimb salvagePeripheral artery disease

Identifiers

PMID40628923
PMCPMC12238340

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.