Observational studyScientific reports2025
Comparison of the outcomes of trabeculectomy and Ab interno trabeculotomy on corneal biomechanics.
Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
This observational cohort study aimed at comparing the postoperative changes in corneal biomechanical properties between trabeculectomy and ab interno trabeculotomy. The study included 46 eyes undergoing trabeculectomy (TLE group) and 92 eyes undergoing ab interno trabeculotomy with lens reconstruction (µLOT + LR group). Corneal hysteresis (CH), which represents corneal damping capacity, along with stiffness parameter A1 (SP-A1) and stress-strain index (SSI), which represent corneal stiffness, were measured preoperatively using the Ocular Response Analyzer and Corneal Visualization Scheimpflug Technology (Corvis ST), respectively. Changes in these parameters 12 months after surgery were analyzed and compared between the groups. Baseline IOP and biomechanical parameters were comparable between both groups. Both surgeries significantly reduced IOP after 12 months, with a greater reduction in the TLE group than in the µLOT + LR group (- 7.4 vs. -3.8 mmHg). Corvis ST parameters showed significant changes postoperatively, with greater reductions in SP-A1 and SSI in the TLE group. CH increased significantly in both groups, but the ratio of the change in CH to the change in IOP (ΔCH/ΔGAT-IOP) was greater in the µLOT + LR group. In conclusions, the cornea exhibited greater softening following TLE compared to µLOT + LR, suggesting a more substantial reduction in IOP. Clinicians should consider the potential bias for IOP measurement due to corneal softening. In contrast, the increase in CH per reduction in IOP was more pronounced after µLOT + LR. These findings highlight the importance of recognizing surgery-induced biomechanical changes when interpreting postoperative IOP measurements, as well as their potential role in predicting long-term glaucoma progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.