ArticleScientific reports2025
Fabrication of a sponge-like protein based hydrogel incorporating fluconazole against Candida species as a potential treatment for vulvovaginal candidiasis infection.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Development of Nigella sativa essential oil loaded keratin/gelatin cryogel with antimicrobial and antioxidant properties for wound dressing.Scientific reports · 2026Article
- Biomimetic polymers and their characterization: toward sustainable materials using synthetic biology.Frontiers in chemistry · 2026Review
- Antimicrobial and Antioxidant Effects of Aqueous, Methanolic, and a Deep Eutectic Solvent-Based Extracts ofScientifica · 2026Article
- Effect of Gellan Gum on the Properties of Collagen-HPMC Freeze-Dried Hydrogels for Mucosal Administration.Gels (Basel, Switzerland) · 2025Article
- Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances.International journal of biomaterials · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
Vulvovaginal candidiasis is a common fungal infection in the reproductive age group of women with an estimated 70-75% of women infected at least once in their life cycle. A chronic condition, recurrent vulvovaginal candidiasis, significantly affects the quality of life in women globally. Hydrogel-based wound dressing has emerged as effective choices for wound closure, as they can mimic the structure and physicochemical properties of the extracellular matrix. However, they are frequently linked with limited biocompatibility, and a deficiency in antifungal activities. Herein, a biocompatible composite sponge-like hydrogel with effective antifungal activities is developed for the management of such wound infections. Synthesis and characterization of a sponge-like protein based hydrogels comprising keratin, gelatin (Kr/Gel), and fluconazole (Kr/Gel@Flu) were engineered via a cryogelation process. The formulation was cross-linked by sodium alginate as a cross-linker. The physicochemical properties of the hydrogels were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray. Additional physicochemical characterizations involved its moisture content (3.70 ± 0.83% Kr/Gel@Flu), water vapor transmission rate (1438 g/m
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