Evidence map›Paper›PMID 40628788›Full record

ArticleScientific reports2025

Pulmonary function and motoric cognitive risk syndrome in older adults.

Xiaofu Du, Jingyi Sun, Suhang Song, Xiang Shu, Yun Huang, Hui Liang, Jing Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xiaofu DuZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310,051, Zhejiang, China.
Jingyi SunThe First Clinical College, Chongqing Medical University, Chongqing, Chongqing, 401,331, China.
Suhang SongDepartment of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA, 30,602, USA.ORCID http://orcid.org/0000-0003-1934-632X
Xiang ShuDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10,017, USA.ORCID http://orcid.org/0000-0002-4129-9403
Yun HuangKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310,006, Zhejiang, China.
Hui LiangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310,051, Zhejiang, China. hliang@cdc.zj.cn.
Jing GuoDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Office 1405 Building 15, Hangzhou, 310,053, China. guojingzju@zju.edu.cn.ORCID http://orcid.org/0000-0002-2177-6970

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Poor pulmonary function (PF) has been linked to neurodegenerative disorders. However, the association of PF with motoric cognitive risk syndrome (MCR) which is a prodromal stage of dementia remains unclear. This study aimed to examine the PF-MCR association in older adults. In the English Longitudinal Study of Ageing (ELSA), the PF was quantified with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF), and a composite PF (CPF) indicator. MCR was defined as the presence of subjective memory complaints and slow gait speed. Cox proportional hazards regression models were employed to examine PF-MCR associations. Among 3564 MCR-free participants at baseline, 421 developed an incident MCR over a median follow-up time of 10 (interquartile range [IQR], 4-14) years. In the multivariable analyses, compared with individuals with low CPF (tertile 1, reference), those with medium (tertile 2, hazard ratio [HR] = 0.79, 95% confidence intervals [CI] = 0.61 to 1.01, P = 0.061) and high levels (tertile 3, HR = 0.65, 95% CI = 0.47 to 0.89, P = 0.008) had decreased risks of incident MCR. Similar results were found when analyzing CPF in a continuous form (HR = 0.73, 95% CI = 0.62 to 0.85, P < 0.001). We also found significantly inverse associations of FVC, FEV1, and PEF with MCR risk. Our findings indicated that high PF is associated with decreased MCR risks. Early monitoring of PF and interventions for PF maintenance may assist in the prevention of MCR.

Indexed as

Cognitive DysfunctionLungAgedAged, 80 and overAgingFemaleForced Expiratory VolumeHumansLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsRespiratory Function TestsRisk FactorsSyndromeVital CapacityEpidemiologyMotoric cognitive risk syndromeOlder adultsPulmonary function

Identifiers

PMID40628788
PMCPMC12238228

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.