ArticleNature communications2025
Distinct echinocandin responses of Candida albicans and Candida auris cell walls revealed by solid-state NMR.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Rethinking the immune recognition of cell walls in human fungal pathogens: Mechanisms, controversies and translational significance.Virulence · 2026Review
- Pathogenicity and virulence ofVirulence · 2026Review
- A bipartite glucan synthase-remodeler module organizes branched glucan assembly in the fungal cell wall.Nature communications · 2026Article
- The Structure, Biosynthesis, and Function of β-1,6-Glucan in the Fungal Cell Wall.Biomolecules · 2026Review
- Reactive Oxygen Species-Responsive Signaling Networks and Oxidative Stress Adaptation in Critical Priority Fungal Pathogens.Journal of fungi (Basel, Switzerland) · 2026Review
- Cascading damage toProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Contrasting Biofilm-Modulating Effects of Polymeric Quaternary Ammonium Compounds on the Pathogenic YeastsACS omega · 2026Article
- Perturbing glycosylphosphatidylinositol (GPI)-anchor biosynthesis alters cell wall architecture and modulates fungal morphology.bioRxiv : the preprint server for biology · 2026Article
- Crystal Facet-Polysaccharide Matching in CFS-P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Structural evolution of a fungal cell wall protein family for β-glucan-binding and cell separation.mBio · 2026Article
- Chaotropic ions reshape the cell wall of the obligate halophile aspergillus atacamensis: Insights from solid-state NMR.Carbohydrate polymers · 2026Article
- α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in anJournal of the American Chemical Society · 2026Article
- The Essential Rot1 Protein Links Glycosylation, Cell Wall Integrity, and Pathogenic Development inJournal of fungi (Basel, Switzerland) · 2026Article
- Article
- Pseudolaric Acid B Combats Drug-Resistant Candida albicans Infection via Dual-Action Mechanisms of Direct Antifungals and Vaginal Microbiota Restoration.Microbial biotechnology · 2026Article
- Genomic Analysis Reveals Diversified and Stress-Responsive Transport Repertoire inJournal of fungi (Basel, Switzerland) · 2026Article
- Significant Activity of Pytren-2Q, a 2‑Quinoline Polyamine Compound, against High-Concern Human Pathogenic Fungi.ACS omega · 2026Article
- Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi.Current biology : CB · 2026Article
- Chaotropic Ions Reshape the Cell Wall of the Obligate HalophilebioRxiv : the preprint server for biology · 2026Article
- Review
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Authors and funding
11 authors.
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Abstract
Invasive candidiasis affects 1.6 million people annually, with high mortality among immunocompromised and hospitalized patients. Echinocandins are frontline antifungals, but rising resistance limits their efficacy. Here, we show that Candida albicans and multidrug-resistant Candida auris share a conserved cell wall architecture yet differ markedly in their adaptive responses to echinocandins. Solid-state NMR reveals that both species possess a rigid inner layer of tightly associated chitin microfibrils and β-1,3-glucans, supported by a flexible matrix of β-1,6-glucans and additional β-1,3-glucans. Outer mannan fibrils rely on α-1,2-linked sidechains to maintain contact with the inner wall. In both species, caspofungin rigidifies β-1,6-glucans and mannan sidechains and reduces water permeability during β-1,3-glucan depletion; however, C. albicans undergoes wall thickening and alterations in chitin and glucan dynamics, whereas C. auris maintains integrity through β-1,6-glucan upregulation. Deletion of KRE6a, which encodes β-1,6-glucan synthase, reduces echinocandin susceptibility in C. auris, further highlighting β-1,6-glucan's critical role in adaptive remodeling.
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