Evidence map›Paper›PMID 40628745›Full record

ArticleScientific reports2025

Immune cells mediate the association between the plasma lipidome and pancreatic cancer: a Mendelian randomization analysis.

Chunhong Ma, Dandan Liu, Changchun Ye, Zilu Chen, Ranran Kong, Jianzhong Li, Xuejun Sun, Zhengshui Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chunhong MaDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Dandan LiuDepartment of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Changchun YeDepartment of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 7100061, Shaanxi, China.
Zilu ChenDepartment of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 7100061, Shaanxi, China.
Ranran KongDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Jianzhong LiDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Xuejun SunDepartment of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 7100061, Shaanxi, China. sunxy@mail.xjtu.edu.cn.
Zhengshui XuDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China. xuzhengshui@xjtu.edu.cn.

Funding

National Natural Science Foundation of China 82303811National Natural Science Foundation of China 82373002Natural Science Basic Research Program of Shaanxi Province 2023-JC-QN-0840
6 · The paper itself

Abstract

The plasma liposome was associated with pancreatic cancer (PC) but the specific mechanism was still unclear. We aim to investigate the relationship between the plasma lipidome and PC risk, as well as the mediating roles of immune cells. Based on summary genome-wide association study (GWAS) statistics of 179 plasma lipidomes, 791 immune cells, and PC patients of European ancestry, two-sample MR analysis was utilized to identify the relationship between the lipidome and PC. Then, the two-step MR method was used to investigate the mediating role of immune cells and calculate the mediation effects. Sensitivity analysis was employed to evaluate the reliability of the findings. According to the inverse variance weighted (IVW) results, higher phosphatidylcholine (O-16:0_20:4) (P = 0.0248), phosphatidylinositol (18:0_20:4) (P = 0.0268), triacylglycerol (54:6) (P = 0.0415), and sterol ester (27:1/15:0) (P = 0.0138) levels reduced PC risk, while phosphatidylcholine (16:0_20:3) (P = 0.0295) and higher sphingomyelin (d40:1) (P = 0.0217) levels increased PC risk. Additionally, 22 immune cells had an effect on PC. Among those, only CD4 Regulatory T (Treg) AC cells played a mediating role between phosphatidylinositol (18:0_20:4) and PC (proportion mediated: 10.5%). No significant heterogeneity or pleiotropy was observed. The present study showed that PC risk was impacted by phosphatidylcholine, phosphatidylinositol, triacylglycerol, sterol ester, and sphingomyelin levels. The causal relationship between phosphatidylinositol (18:0_20:4) and PC was mediated by CD4 Treg AC cells, which provides insight for immunotherapy.

Indexed as

LipidomicsLipidsPancreatic NeoplasmsGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisPhosphatidylcholinesPolymorphism, Single NucleotideLipidsPhosphatidylcholinesImmune cellMendelian randomization analysisPancreatic cancerPlasma lipidome

Identifiers

PMID40628745
PMCPMC12238245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.