Evidence map›Paper›PMID 40628739›Full record

ArticleNature communications2025

Unveiling aging heterogeneities in human dermal fibroblasts via nanosensor chemical cytometry.

Youngho Song, Inwoo Seo, Changyu Tian, Jiseon An, Seongcheol Park, Jiyu Hyun, Seunghyuk Jung, Hyun Su Park, Hyun-Ji Park, Suk Ho Bhang and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Youngho Song *School of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.ORCID http://orcid.org/0009-0004-4718-860X
Inwoo Seo *School of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.ORCID http://orcid.org/0000-0003-3988-0378
Changyu TianSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Jiseon AnSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Seongcheol ParkSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Jiyu HyunSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Seunghyuk JungDepartment of Applied Chemistry & Biological Engineering, Ajou University, Suwon, Republic of Korea.
Hyun Su ParkSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Hyun-Ji ParkAdvanced College of Bio-Convergence Engineering, Ajou University, Suwon, Republic of Korea.ORCID http://orcid.org/0000-0001-9688-4418
Suk Ho BhangSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea. sukhobhang@skku.edu.ORCID http://orcid.org/0000-0003-3002-0590
Soo-Yeon ChoSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea. sooyeonc@skku.edu.ORCID http://orcid.org/0000-0001-6294-1154

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging heterogeneity in tissue-regenerative cells leads to variable therapeutic outcomes, complicating quality control and clinical predictability. Conventional analytical methods relying on labeling or cell lysis are destructive and incompatible with downstream therapeutic applications. Here we show a label-free, nondestructive single-cell analysis platform based on nanosensor chemical cytometry (NCC), integrated with automated hardware and deep learning. nIR fluorescent single-walled carbon nanotube arrays in a microfluidic channel, together with photonic nanojet lensing, extract four key aging phenotypes (cell size, shape, refractive index, and H

Indexed as

Cellular SenescenceDermisFibroblastsFlow CytometryNanotechnologySingle-Cell AnalysisDeep LearningHumansHydrogen PeroxideNanotubes, CarbonPhenotypeHydrogen PeroxideNanotubes, Carbon

Identifiers

PMID40628739
PMCPMC12238425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.