Evidence map›Paper›PMID 40628712›Full record

ArticleTranslational psychiatry2025

Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study.

Liang-Yu Huang, Chen-Chen Tan, Wei Xu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liang-Yu HuangDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Chen-Chen TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Wei XuDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China. dr_xuwei@qdu.edu.cn.ORCID http://orcid.org/0000-0002-3310-5875
Lan TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China. dr.tanlan@163.com.ORCID http://orcid.org/0000-0002-8759-7588
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
NCATS NIH HHS UL1 TR002369NIA NIH HHS P30 AG072947NIA NIH HHS U01 AG024904Taishan Scholar Foundation of Shandong Province NO.tsqn202211375
6 · The paper itself

Abstract

Progranulin (PGRN) and soluble triggering receptor expressed on myeloid cells-2 (sTREM2) are emerging biomarkers of Alzheimer's disease (AD). This study explores the roles of their interplay in modulating amyloid pathology. We analyzed data from 905 participants (mean age = 62.0) in the CABLE cohort and 973 participants (mean age = 73.1) in the ADNI, classified using the A/T/N biomarker framework. One-way ANOVA was used to assess whether cerebrospinal fluid (CSF) PGRN and sTREM2 differed across biomarker profiles and clinical stages. Multiple linear regression models and linear mixed-effects models were used to test the relationships among PGRN, sTREM2, and CSF Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesMembrane GlycoproteinsPeptide FragmentsProgranulinsReceptors, ImmunologicAgedAged, 80 and overBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersGRN protein, humanMembrane GlycoproteinsPeptide FragmentsProgranulinsReceptors, ImmunologicTREM2 protein, human

Identifiers

PMID40628712
PMCPMC12238292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.