Evidence map›Paper›PMID 40628708›Full record

Trial reportNutrition & diabetes2025

Acute glycaemic response of orange juice consumption with breakfast in individuals with type 2 diabetes: a randomized cross-over trial.

Kenneth Verboven, Lisa Van Ryckeghem, Ralf Schweiggert, Christof B Steingass, Tin Gojevic, Carrie H S Ruxton, Dominique Hansen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition & diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kenneth VerbovenBIOMED Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium. kenneth.verboven@uhasselt.be.ORCID 0000-0002-3799-5430
Lisa Van RyckeghemBIOMED Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Ralf SchweiggertChair of Analysis and Technology of Plant-based Foods, Department of Beverage Research, Geisenheim University, Geisenheim, Germany.
Christof B SteingassChair of Analysis and Technology of Plant-based Foods, Department of Beverage Research, Geisenheim University, Geisenheim, Germany.
Tin GojevicBIOMED Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Carrie H S RuxtonNutrition Communications, Cupar, UK.
Dominique HansenBIOMED Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesSugar-sweetened beverages are associated with an increased risk of obesity and type 2 diabetes (T2DM) and show clear differential metabolic responses compared with 100% fruit juice, which is unsweetened by law. This study investigated whether the postprandial glycaemic response following a standardized breakfast differed when accompanied by 100% orange juice, equivalent whole orange, or a sugar-sweetened control beverage in individuals with well-controlled T2DM. SUBJECTS/

methodsFifteen individuals with T2DM (60 ± 6 y; BMI 28.7 ± 5.0 kg/m², HbA1C 49 ± 3 mmol/mol (6.6 ± 0.3%)) participated in this randomized cross-over trial. They consumed a standardized breakfast served with either 250 mL of 100% orange juice, a sugar-sweetened orange-flavoured beverage or whole orange pieces with identical total sugar content. Postprandial glycaemic and insulinaemic responses were checked during 4 h.

resultsFollowing a single intake, no significant differences were found in acute glucose or insulin responses (expressed as total or incremental area under the curve or peak values; p

conclusionAcute glycaemic control in individuals with well-controlled T2DM is not significantly influenced by serving orange juice, whole orange pieces or a sugar-sweetened beverage with a standard high-carbohydrate meal.

Indexed as

Blood GlucoseBreakfastCitrus sinensisDiabetes Mellitus, Type 2Fruit and Vegetable JuicesAgedCross-Over StudiesFemaleGlycated HemoglobinHumansInsulinMaleMiddle AgedPostprandial PeriodSugar-Sweetened BeveragesBlood GlucoseGlycated HemoglobinInsulin

Identifiers

PMID40628708
PMCPMC12238372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.