Evidence map›Paper›PMID 40628504›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

Characteristics and differential diagnosis of common verrucous proliferative skin diseases under dermoscopy and reflectance confocal microscopy.

Lu Zhou, Yule Fu, Jian Huang, Zhen Tang, Jianyun Lu, Lina Tan, Dan Wang, Jinrong Zeng, Jia Wang, Lihua Gao

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Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Lu ZhouDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013. 290991732@qq.com.
Yule FuXiangya School of Medicine, Central South University, Changsha 410013, China. fu1375415081@163.com.
Jian HuangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013.
Zhen TangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013.
Jianyun LuDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013.
Lina TanDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013.
Dan WangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013.
Jinrong ZengDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013.
Jia WangXiangya School of Medicine, Central South University, Changsha 410013, China.
Lihua GaoDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013. 49516596@qq.com.

Funding

the Project of Health Committee of Hunan Province D202304128868This is an open access article under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International CC BY-NC-ND 4.0 and //creativecommons.org/licenses/by-nc-nd/4.0/
6 · The paper itself

Abstract

objectivesVerrucous epidermal nevus (VEN), seborrheic keratosis (SK), verruca plana (VP), verruca vulgaris (VV), and nevus sebaceous (NS) are common verrucous proliferative skin diseases with similar clinical appearances, often posing diagnostic challenges. Dermoscopy and reflectance confocal microscopy (RCM) can aid in their differentiation, yet their specific features under these tools have not been systematically described. This study aims to summarize and analyze the dermoscopic and RCM features of VEN, SK, VP, VV, and NS.

methodsA total of 121 patients with histopathologically confirmed verrucous proliferative skin diseases were enrolled. Dermoscopy and RCM imaging was used to observe and analyze the microscopic features of these conditions.

resultsUnder dermoscopy, the 5 diseases displayed distinct characteristics: VEN typically showed gyriform structures; SK was characterized by gyriform structures, comedo-like openings, and milia-like cysts; VP and VV featured dotted vessels and frogspawn-like structures; NS presented as brownish-yellow globules. RCM revealed shared features such as hyperkeratosis and acanthosis across all 5 diseases. Specific features included gyriform structures and elongated rete ridges in VEN; pseudocysts and gyriform structures in SK; evenly distributed ring-like structures in VP; vacuolated cells and papillomatous proliferation in VV; and frogspawn-like structures in NS.

conclusionsThese 5 verrucous proliferative skin conditions exhibit distinguishable features under both dermoscopy and RCM. The combination of these 2 noninvasive imaging modalities holds significant clinical value for the differential diagnosis of verrucous proliferative skin diseases.

Indexed as

DermoscopyNevus, Sebaceous of JadassohnSkin DiseasesWartsAdolescentAdultAgedChildChild, PreschoolDiagnosis, DifferentialFemaleHumansKeratosis, SeborrheicMaleMicroscopy, ConfocalMiddle Ageddermoscopynevus sebaceousreflectance confocal microscopyseborrheic keratosisverruca planaverruca vulgarisverrucous epidermal nevusverrucous proliferation

Identifiers

PMID40628504
PMCPMC13345768

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