Evidence map›Paper›PMID 40628436›Full record

SynthesisSaudi medical journal2025

Comparison between ondansetron and granisetron in preventing nausea and vomiting after laparoscopic cholecystectomy: A systematic review and meta-analysis.

Waleed D Khubzan, Mohammed H Albagieh, Ruyuf A Nathif, Waad M Alshamrani, Nawaf S Alharbi, Reem A Sharahili, Naif M Alsaeed, Mohammedeid M Mahfouz

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Waleed D KhubzanFrom the Faculty of Medicine (Khubzan); from the Department of Surgery (Mahfouz), Faculty of Medicine, Taif University, Taif, from the Faculty of Medicine (Albagieh, Alsaeed), Imam Mohammed Ibn Saud Islamic University, from the Intensive Care Unit (Nathif), Ministry of National Guard Health Affairs, Riyadh, from the Faculty of Medicine (Alshamrani), University of Jeddah, Jeddah, from the Faculty of Medicine (Alharbi), Unaizah University, Unaizah, and from the Faculty of Medicine (Sharahili), Jazan University, Jazan, Kingdom of Saudi Arabia.ORCID https://orcid.org/0009-0009-9943-9585
Mohammed H AlbagiehFrom the Faculty of Medicine (Khubzan); from the Department of Surgery (Mahfouz), Faculty of Medicine, Taif University, Taif, from the Faculty of Medicine (Albagieh, Alsaeed), Imam Mohammed Ibn Saud Islamic University, from the Intensive Care Unit (Nathif), Ministry of National Guard Health Affairs, Riyadh, from the Faculty of Medicine (Alshamrani), University of Jeddah, Jeddah, from the Faculty of Medicine (Alharbi), Unaizah University, Unaizah, and from the Faculty of Medicine (Sharahili), Jazan University, Jazan, Kingdom of Saudi Arabia.
Ruyuf A NathifFrom the Faculty of Medicine (Khubzan); from the Department of Surgery (Mahfouz), Faculty of Medicine, Taif University, Taif, from the Faculty of Medicine (Albagieh, Alsaeed), Imam Mohammed Ibn Saud Islamic University, from the Intensive Care Unit (Nathif), Ministry of National Guard Health Affairs, Riyadh, from the Faculty of Medicine (Alshamrani), University of Jeddah, Jeddah, from the Faculty of Medicine (Alharbi), Unaizah University, Unaizah, and from the Faculty of Medicine (Sharahili), Jazan University, Jazan, Kingdom of Saudi Arabia.
Waad M AlshamraniFrom the Faculty of Medicine (Khubzan); from the Department of Surgery (Mahfouz), Faculty of Medicine, Taif University, Taif, from the Faculty of Medicine (Albagieh, Alsaeed), Imam Mohammed Ibn Saud Islamic University, from the Intensive Care Unit (Nathif), Ministry of National Guard Health Affairs, Riyadh, from the Faculty of Medicine (Alshamrani), University of Jeddah, Jeddah, from the Faculty of Medicine (Alharbi), Unaizah University, Unaizah, and from the Faculty of Medicine (Sharahili), Jazan University, Jazan, Kingdom of Saudi Arabia.
Nawaf S AlharbiFrom the Faculty of Medicine (Khubzan); from the Department of Surgery (Mahfouz), Faculty of Medicine, Taif University, Taif, from the Faculty of Medicine (Albagieh, Alsaeed), Imam Mohammed Ibn Saud Islamic University, from the Intensive Care Unit (Nathif), Ministry of National Guard Health Affairs, Riyadh, from the Faculty of Medicine (Alshamrani), University of Jeddah, Jeddah, from the Faculty of Medicine (Alharbi), Unaizah University, Unaizah, and from the Faculty of Medicine (Sharahili), Jazan University, Jazan, Kingdom of Saudi Arabia.
Reem A SharahiliFrom the Faculty of Medicine (Khubzan); from the Department of Surgery (Mahfouz), Faculty of Medicine, Taif University, Taif, from the Faculty of Medicine (Albagieh, Alsaeed), Imam Mohammed Ibn Saud Islamic University, from the Intensive Care Unit (Nathif), Ministry of National Guard Health Affairs, Riyadh, from the Faculty of Medicine (Alshamrani), University of Jeddah, Jeddah, from the Faculty of Medicine (Alharbi), Unaizah University, Unaizah, and from the Faculty of Medicine (Sharahili), Jazan University, Jazan, Kingdom of Saudi Arabia.
Naif M AlsaeedFrom the Faculty of Medicine (Khubzan); from the Department of Surgery (Mahfouz), Faculty of Medicine, Taif University, Taif, from the Faculty of Medicine (Albagieh, Alsaeed), Imam Mohammed Ibn Saud Islamic University, from the Intensive Care Unit (Nathif), Ministry of National Guard Health Affairs, Riyadh, from the Faculty of Medicine (Alshamrani), University of Jeddah, Jeddah, from the Faculty of Medicine (Alharbi), Unaizah University, Unaizah, and from the Faculty of Medicine (Sharahili), Jazan University, Jazan, Kingdom of Saudi Arabia.
Mohammedeid M MahfouzFrom the Faculty of Medicine (Khubzan); from the Department of Surgery (Mahfouz), Faculty of Medicine, Taif University, Taif, from the Faculty of Medicine (Albagieh, Alsaeed), Imam Mohammed Ibn Saud Islamic University, from the Intensive Care Unit (Nathif), Ministry of National Guard Health Affairs, Riyadh, from the Faculty of Medicine (Alshamrani), University of Jeddah, Jeddah, from the Faculty of Medicine (Alharbi), Unaizah University, Unaizah, and from the Faculty of Medicine (Sharahili), Jazan University, Jazan, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo find the most optimal drug for post-operative nausea and vomiting (PONV) prophylaxis after laparoscopic cholecystectomy (LC) by comparing ondansetron and granisetron.

methodsWe carried out our study in adherence to the Preferred Reporting Items for Systematic reviews and Meta-Analyses instructions. Google Scholar, PubMed, Web of Science, and Ovid MEDLINE (through November 2024) were searched for studies comparing ondansetron and granisetron after LC. Primary outcomes include the incidence of PONV at 0-12 hour and 0-24 hour time points; secondary outcomes included rescue anti-emetic use and adverse effects. All data analysis and the quality assessment were carried out by utilizing review manager 5.4.

resultsA total of 21 studies encompassing 1539 patients were included; 17 of them were eligible for meta-analysis. Compared with ondansetron, granisetron was effective in reducing nausea (15.2% vs. 25.4%; risk ratio [RR]=1.67, I

conclusionAccording to our findings, granisetron was superior in preventing PONV when compared to ondansetron following LC, with fewer rescue anti-emetics and adverse effects. Further research on cost-effectiveness and optimal dosing is required.

Indexed as

AntiemeticsCholecystectomy, LaparoscopicGranisetronOndansetronPostoperative Nausea and VomitingHumansAntiemeticsGranisetronOndansetrongranisetronlaparoscopic cholecystectomyondansetronPONV

Identifiers

PMID40628436
PMCPMC12251592

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.