SynthesisSaudi medical journal2025
Rehmannia glutinosa for perimenopausal syndrome in patients with breast cancer: A systematic review and meta-analysis.
Synthesis in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The efficacy and safety of Femoston combined with Baoqing granules for kidney Yin deficiency in perimenopausal women: a randomized, double-blind, placebo-controlled trial.Frontiers in endocrinology · 2026Trial
- Clinical evidence on integrated Chinese-Western medicine for perimenopausal syndrome.Integrative medicine research · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo carry out a quantitative assessment of the therapeutic effect of Chinese herbal medicine (CHM), with Rehmannia glutinosa as the main ingredient, in treating perimenopausal syndrome (PMS) in breast cancer patients.
methodsRandomized controlled trials (RCTs) comparing CHM with Rehmannia glutinosa as the principal ingredient and Western medicine in treating PMS among breast cancer patients were retrieved from multiple databases. These databases included PubMed, Cochrane library, Embase, China National Knowledge Infrastructure, Wanfang Data, China Science and Technology Journal Database, and China Biology Medicine Database. The primary outcome was the change in the Kupperman index by the end of the follow-up period. Secondary outcomes were changes in Karnofsky performance status (KPS), the functional assessment of cancer therapy - breast (FACT-B), the percentages of T-cells, levels of gonadal hormones, and tumor markers in peripheral blood at the end of follow-up, and adverse events.
resultsThe meta-analysis included 17 RCTs involving 1,139 patients showing that CHM with Rehmannia glutinosa as the monarch drug significantly improved the Kupperman index (MD= -12.79,
conclusionThese data suggest that CHM with Rehmannia glutinosa as the monarch drug may be applied in the treatment of PMS in patients with breast cancer. These results should be considered in the context of the methodological flaws and high heterogeneity of the included RCTs.
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