Evidence map›Paper›PMID 40628428›Full record

ArticleSaudi medical journal2025

Effectiveness of dupilumab in chronic rhinosinusitis with nasal polyps: A retrospective study of clinical and imaging outcomes.

Mohammed A Alhejaily, Musallam Kashoob, Shatha Y AlGhamdi, Muhannad A Alomar, Yazeed A Alomar, Rawan S Alzayed, Amany M Altoies, Ahmad Alroqi

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In one paragraph

Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammed A AlhejailyFrom the Department of Otolaryngology-Head and Neck Surgery (Alhejaily), Prince Sultan Armed Forces Hospital, Ministry of Defense Health Services, Al-Medinah Al-Munawarah, from the Department of Otolaryngology, Head and Neck Surgery (Kashoob); from the College of Medicine (M. A. Alomar, Y. A. Alomar, Alzayed, Altoies), Department of Otolaryngology-Head and Neck Surgery (Alrouqi), College of Medicine, King Saud University, Riyadh, from the Department of Otolaryngology, Head and Neck Surgery (AlGhamdi), College of Medicine, King Faisal University, Hofuf, Kingdom of Saudi Arabia, and from the Department of Otolaryngology, Head and Neck Surgery (Kashoob), Sultan Qaboos Hospital, Salalah, Oman.ORCID https://orcid.org/0009-0005-0943-4926
Musallam KashoobFrom the Department of Otolaryngology-Head and Neck Surgery (Alhejaily), Prince Sultan Armed Forces Hospital, Ministry of Defense Health Services, Al-Medinah Al-Munawarah, from the Department of Otolaryngology, Head and Neck Surgery (Kashoob); from the College of Medicine (M. A. Alomar, Y. A. Alomar, Alzayed, Altoies), Department of Otolaryngology-Head and Neck Surgery (Alrouqi), College of Medicine, King Saud University, Riyadh, from the Department of Otolaryngology, Head and Neck Surgery (AlGhamdi), College of Medicine, King Faisal University, Hofuf, Kingdom of Saudi Arabia, and from the Department of Otolaryngology, Head and Neck Surgery (Kashoob), Sultan Qaboos Hospital, Salalah, Oman.
Shatha Y AlGhamdiFrom the Department of Otolaryngology-Head and Neck Surgery (Alhejaily), Prince Sultan Armed Forces Hospital, Ministry of Defense Health Services, Al-Medinah Al-Munawarah, from the Department of Otolaryngology, Head and Neck Surgery (Kashoob); from the College of Medicine (M. A. Alomar, Y. A. Alomar, Alzayed, Altoies), Department of Otolaryngology-Head and Neck Surgery (Alrouqi), College of Medicine, King Saud University, Riyadh, from the Department of Otolaryngology, Head and Neck Surgery (AlGhamdi), College of Medicine, King Faisal University, Hofuf, Kingdom of Saudi Arabia, and from the Department of Otolaryngology, Head and Neck Surgery (Kashoob), Sultan Qaboos Hospital, Salalah, Oman.
Muhannad A AlomarFrom the Department of Otolaryngology-Head and Neck Surgery (Alhejaily), Prince Sultan Armed Forces Hospital, Ministry of Defense Health Services, Al-Medinah Al-Munawarah, from the Department of Otolaryngology, Head and Neck Surgery (Kashoob); from the College of Medicine (M. A. Alomar, Y. A. Alomar, Alzayed, Altoies), Department of Otolaryngology-Head and Neck Surgery (Alrouqi), College of Medicine, King Saud University, Riyadh, from the Department of Otolaryngology, Head and Neck Surgery (AlGhamdi), College of Medicine, King Faisal University, Hofuf, Kingdom of Saudi Arabia, and from the Department of Otolaryngology, Head and Neck Surgery (Kashoob), Sultan Qaboos Hospital, Salalah, Oman.
Yazeed A AlomarFrom the Department of Otolaryngology-Head and Neck Surgery (Alhejaily), Prince Sultan Armed Forces Hospital, Ministry of Defense Health Services, Al-Medinah Al-Munawarah, from the Department of Otolaryngology, Head and Neck Surgery (Kashoob); from the College of Medicine (M. A. Alomar, Y. A. Alomar, Alzayed, Altoies), Department of Otolaryngology-Head and Neck Surgery (Alrouqi), College of Medicine, King Saud University, Riyadh, from the Department of Otolaryngology, Head and Neck Surgery (AlGhamdi), College of Medicine, King Faisal University, Hofuf, Kingdom of Saudi Arabia, and from the Department of Otolaryngology, Head and Neck Surgery (Kashoob), Sultan Qaboos Hospital, Salalah, Oman.
Rawan S AlzayedFrom the Department of Otolaryngology-Head and Neck Surgery (Alhejaily), Prince Sultan Armed Forces Hospital, Ministry of Defense Health Services, Al-Medinah Al-Munawarah, from the Department of Otolaryngology, Head and Neck Surgery (Kashoob); from the College of Medicine (M. A. Alomar, Y. A. Alomar, Alzayed, Altoies), Department of Otolaryngology-Head and Neck Surgery (Alrouqi), College of Medicine, King Saud University, Riyadh, from the Department of Otolaryngology, Head and Neck Surgery (AlGhamdi), College of Medicine, King Faisal University, Hofuf, Kingdom of Saudi Arabia, and from the Department of Otolaryngology, Head and Neck Surgery (Kashoob), Sultan Qaboos Hospital, Salalah, Oman.
Amany M AltoiesFrom the Department of Otolaryngology-Head and Neck Surgery (Alhejaily), Prince Sultan Armed Forces Hospital, Ministry of Defense Health Services, Al-Medinah Al-Munawarah, from the Department of Otolaryngology, Head and Neck Surgery (Kashoob); from the College of Medicine (M. A. Alomar, Y. A. Alomar, Alzayed, Altoies), Department of Otolaryngology-Head and Neck Surgery (Alrouqi), College of Medicine, King Saud University, Riyadh, from the Department of Otolaryngology, Head and Neck Surgery (AlGhamdi), College of Medicine, King Faisal University, Hofuf, Kingdom of Saudi Arabia, and from the Department of Otolaryngology, Head and Neck Surgery (Kashoob), Sultan Qaboos Hospital, Salalah, Oman.
Ahmad AlroqiFrom the Department of Otolaryngology-Head and Neck Surgery (Alhejaily), Prince Sultan Armed Forces Hospital, Ministry of Defense Health Services, Al-Medinah Al-Munawarah, from the Department of Otolaryngology, Head and Neck Surgery (Kashoob); from the College of Medicine (M. A. Alomar, Y. A. Alomar, Alzayed, Altoies), Department of Otolaryngology-Head and Neck Surgery (Alrouqi), College of Medicine, King Saud University, Riyadh, from the Department of Otolaryngology, Head and Neck Surgery (AlGhamdi), College of Medicine, King Faisal University, Hofuf, Kingdom of Saudi Arabia, and from the Department of Otolaryngology, Head and Neck Surgery (Kashoob), Sultan Qaboos Hospital, Salalah, Oman.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate dupilumab's outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP) cases.

methodsA retrospective analysis was carried out at Dr. Sulaiman Al Habib Hospitals, Riyadh, Saudi Arabia on 145 adult CRSwNP patients treated with dupilumab between January 2020 and December 2023 following the European position paper on rhinosinusitis and nasal polyps 2020 guidelines. Primary outcomes included changes in Lund-Mackay computed tomography (CT) scores, immunoglobulin E levels, and visual analog scale (VAS) smell score over +12 months.

resultsSignificant improvements were noted post-treatment. Lund-Mackay CT scores decreased from 12.5 to 5.5 (

conclusionThis study supports dupilumab's effectiveness in treating severe CRSwNP, showing significant improvements in CT imaging and overall medical condition over 12 months. Dupilumab reduced systemic corticosteroid use and rescue surgeries. While promising, further trials are needed to validate its use as monotherapy. Identifying those who gain most from biologic therapy is crucial.

Indexed as

Antibodies, Monoclonal, HumanizedNasal PolypsRhinitisSinusitisAdultChronic DiseaseFemaleHumansImmunoglobulin EMaleMiddle AgedRetrospective StudiesRhinosinusitisTomography, X-Ray ComputedTreatment OutcomeAntibodies, Monoclonal, HumanizeddupilumabImmunoglobulin Easthmabiological therapydupilumabnasal polyposisrhinosinusitistype 2 inflammation

Identifiers

PMID40628428
PMCPMC12251548

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