Evidence map›Paper›PMID 40627844›Full record

ArticleACS applied materials & interfaces2025

tRNA-Derived Small RNA Accelerates Tumorigenesis through Crosstalk with Tumor-Associated Macrophages, and Downregulation with Cell Membrane-Modified Polymer Nanoparticles Enables Treatment Response.

Zhou Zhou, Bairong Chen, Jibin Liu, Wei Feng, Zhaozheng Ren, Kangfeng Jin, Yi Li, Linling Ju, Lin Chen, Guang Zhu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhou ZhouResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
Bairong ChenResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
Jibin LiuInstitute of Oncology, Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu 226631, China.
Wei FengResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
Zhaozheng RenGrade 22 of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Kangfeng JinResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
Yi LiResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
Linling JuNantong Institute of Liver Diseases, Nantong Third People's Hospital Affiliated Nantong Hospital 3 of Nantong University, Nantong 226006, China.
Lin ChenNantong Institute of Liver Diseases, Nantong Third People's Hospital Affiliated Nantong Hospital 3 of Nantong University, Nantong 226006, China.
Guang ZhuDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 00000, China.ORCID 0000-0003-3802-3446
Feng WangResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.ORCID 0000-0002-4721-1062

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence has shown that tRNA-derived small RNAs (tsRNAs) play pivotal roles in the progression of the majority of malignancies. The tumor microenvironment (TME) is important for hepatocellular carcinoma (HCC) progression. However, how tsRNAs exert their effects through the TME to drive hepatocarcinogenesis is unclear. We revealed that tsr_019759, a tsRNA, was significantly upregulated in HCC, and it promoted HCC growth and metastasis via inhibiting TNFSF15 expression and activating the JAK2/STAT3 signal pathway. Moreover, tsr_019759 could impede the exocrine secretion of TNFSF15, thereby inducing tumor-associated macrophage (TAM) polarization toward the M2 type through inhibiting the DR3/NF-κB signaling pathway. Additionally, M2 TAMs further facilitated HCC development through increasing EGF secretion and activating the EGFR/JAK2/STAT3 signaling pathway. Furthermore, a type of delivery system targeting inhibition of tsr_019759 loaded in HCC cancer cell membrane (CCM)-packed polyethylenimine (PEI)-modified poly lactic-

Indexed as

CarcinogenesisCarcinoma, HepatocellularLiver NeoplasmsNanoparticlesRNA, TransferTumor-Associated MacrophagesAnimalsCell Line, TumorCell MembraneDown-RegulationHumansMiceMice, Inbred BALB CMice, NudePolymersTumor MicroenvironmentPolymersRNA, Transferhepatocellular carcinomahsa_tsr019759nanotherapyTNFSF15tumor-associated macrophages

Identifiers

PMID40627844
PMCPMC12291082

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.