Evidence map›Paper›PMID 40627543›Full record

ArticleeLife2025

Unraveling CRP/cAMP-mediated metabolic regulation in

Han G Ngo, Sayed Golam Mohiuddin, Aina Ananda, Mehmet Orman

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Glycerol-Driven Energy and Proteostasis Underpin Antibiotic Tolerance inbioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Molecular Basis of Persister Awakening and Lag-Phase Recovery inInternational journal of molecular sciences · 2026
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Han G NgoDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, United States.ORCID https://orcid.org/0000-0002-3860-4550
Sayed Golam MohiuddinDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, United States.ORCID https://orcid.org/0000-0001-7613-6324
Aina AnandaDepartment of Biology, Monmouth University, West Long Branch, United States.
Mehmet OrmanDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, United States.ORCID https://orcid.org/0000-0001-8499-9154

Funding

Characterizing a Self-Digesting-Mediated Reversible Drug Tolerance Mechanism in BacteriaR01AI143643 · NIAID · UNIVERSITY OF HOUSTON · PI ORMAN, MEHMET A. · 2020 to 2024
$1.9M
National Science Foundation 2044375NIAID NIH HHS R01 AI143643NIH HHS R01AI143643
6 · The paper itself

Abstract

A substantial gap persists in our comprehension of how bacterial metabolism undergoes rewiring during the transition to a persistent state. Also, it remains unclear which metabolic mechanisms become indispensable for persister cell survival. To address these questions, we directed our efforts towards persister cells in

Indexed as

Cyclic AMPCyclic AMP Receptor ProteinEnergy MetabolismEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialAnti-Bacterial AgentsCitric Acid CycleMicrobial ViabilityAnti-Bacterial Agentscrp protein, E coliCyclic AMPCyclic AMP Receptor ProteinEscherichia coli ProteinsCrp/cAMPE. colienergy metabolisminfectious diseasemicrobiologypersisters

Identifiers

PMID40627543
PMCPMC12237405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.