Evidence map›Paper›PMID 40627443›Full record

ArticleFuture oncology (London, England)2025

The pathway to diagnosis of early-onset colorectal cancer: exploring diagnostic intervals and their effect on outcomes.

Oliver Waddell, Andrew McCombie, Tamara Glyn, John Pearson, Jacqueline Keenan, Frank Frizelle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Age-stratified risk profiles for emergency colorectal cancer resection: A machine-learning analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Oliver WaddellDepartment of Surgery and Critical Care, University of Otago Christchurch, Christchurch, New Zealand.
Andrew McCombieDepartment of Surgery and Critical Care, University of Otago Christchurch, Christchurch, New Zealand.
Tamara GlynDepartment of Surgery and Critical Care, University of Otago Christchurch, Christchurch, New Zealand.
John PearsonBiostatistics and Computational Biology Unit, University of Otago Christchurch, Christchurch, New Zealand.
Jacqueline KeenanDepartment of Surgery and Critical Care, University of Otago Christchurch, Christchurch, New Zealand.
Frank FrizelleDepartment of Surgery and Critical Care, University of Otago Christchurch, Christchurch, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly-onset colorectal cancer, diagnosed before 50 years (EOCRC), is rising. Previous studies suggest younger patients experience longer diagnostic intervals potentially contributing to poorer outcomes. RESEARCH DESIGN AND

methodsA prospective cohort study comparing EOCRC patients in Canterbury, Aotearoa New Zealand, with a control group of late-onset patients (65+ years, LOCRC). Pathways to diagnosis and diagnostic intervals were compared.

resultsSixty-three consecutive EOCRC patients were compared 64 LOCRC patients. The younger cohort was more likely to have advanced disease (stage four in 32% v 17%). Pathways to diagnosis were comparable between the groups (

conclusionPathways to diagnosis were similar between EOCRC and LOCRC patients. Shorter diagnostic intervals were associated with advanced disease, indicating that shortening diagnostic intervals alone may not improve outcomes. Diagnosing CRC prior to symptoms develop (screening) is likely the best way to improve outcomes.

Indexed as

Colorectal NeoplasmsEarly Detection of CancerAdultAgedAged, 80 and overAge of OnsetFemaleHumansMaleMiddle AgedNeoplasm StagingNew ZealandProspective StudiesTime Factorsbowel cancerColorectal cancerearly-onset colorectal cancergeneral surgerysurgical oncology

Identifiers

PMID40627443
PMCPMC12330238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.