Evidence map›Paper›PMID 40627407›Full record

ArticlePrenatal diagnosis2025

Open Spinal Dysraphism Without Hindbrain Herniation-Natural History and Postnatal Outcome.

I Bedei, C C Kik, R Axt-Fliedner, P L J DeKoninck, W Ventura, S Köhler, M Schulze, T Struffert, M Kolodziej, D Diehl and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Prenatal diagnosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

I BedeiDepartment of Prenatal Medicine and Fetal Therapy, Justus-Liebig University Giessen, Giessen, Germany.ORCID 0000-0002-7688-5357
C C KikDepartment of Obstetrics and Gynaecology, Division of Obstetrics and Fetal Medicine, Erasmus MC Sophia Children's Hospital, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-9667-8486
R Axt-FliednerDepartment of Prenatal Medicine and Fetal Therapy, Justus-Liebig University Giessen, Giessen, Germany.
P L J DeKoninckDepartment of Obstetrics and Gynaecology, Division of Obstetrics and Fetal Medicine, Erasmus MC Sophia Children's Hospital, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-4457-0940
W VenturaFetal Medicine Unit at Medicina Fetal Peru & Instituto Nacional Materno-Perinatal, Lima, Peru.ORCID 0000-0002-2888-1394
S KöhlerDepartment of Prenatal Medicine and Fetal Therapy, Philipps University, Marburg, Germany.
M SchulzeDepartment of Neuroradiology, Philipps University, Marburg, Germany.
T StruffertDepartment of Neuroradiology, Justus-Liebig University, Giessen, Germany.
M KolodziejDepartment of Neurosurgery, Justus-Liebig University, Giessen, Germany.
D DiehlDepartment of Pediatric Neurology, Justus-Liebig University Giessen, Giessen, Germany.
B SassDepartment of Neurosurgery, Philipps University, Marburg, Germany.
J K H SpoorDepartment of Pediatric Neurosurgery, Erasmus MC Sophia Children's Hospital, University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-1183-4775
C KeilDepartment of Prenatal Medicine and Fetal Therapy, Philipps University, Marburg, Germany.

Funding

Sophia Foundation (CAM 19-11)
6 · The paper itself

Abstract

objectiveTo report the natural history of fetuses with open spinal dysraphism (OSD) without hindbrain herniation (HBH) during second-trimester evaluation.

methodsA multicenter retrospective cohort study was conducted across three prenatal centers to evaluate fetuses with OSD. We reviewed cases with postnatally confirmed OSD without prenatal HBH at 19-27 weeks. Standardized prenatal evaluation consisted of repetitive ultrasound and magnetic resonance imaging. Postnatal outcome measures involved imaging, intraoperative findings and neurological function tests.

resultsAmong 280 fetuses with OSD, evaluated at a median gestational age of 21 weeks, a total of 12 (4%) lacked HBH. Moderate ventriculomegaly was observed in 33% of cases without HBH. Corpus callosum anomalies were not detected. Postnatally, HBH was present in 50%, while the shunt rate remained low (20%). In 80%, postnatal motor function (MF) was equal to or better based on the anatomical level. In 33%, MF after birth declined in comparison to the first fetal functional assessment in the second trimester.

conclusionFetuses with OSD and absent HBH in the second trimester demonstrate a low postnatal shunt rate. MF was frequently impaired at the initial second-trimester assessment, and in about a third of cases, postnatal MF seemed to have worsened. These findings may inform counseling and question the place of fetal surgery for this subgroup.

Indexed as

Spina Bifida CysticaAdultEncephaloceleFemaleGestational AgeHumansInfant, NewbornMagnetic Resonance ImagingPregnancyPregnancy Trimester, SecondRetrospective StudiesRhombencephalonUltrasonography, Prenatal

Identifiers

PMID40627407
PMCPMC12322258

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.