Evidence map›Paper›PMID 40627393›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

EDNRB2 regulates fate, migration, and maturation of hair cell precursors in regenerating avian auditory epithelium explants.

Marie Takeuchi, Mami Matsunaga, Tomoko Kita, Koji Nishimura, Yosuke Tona, Koichi Omori, Tatsuya Katsuno, Takayuki Nakagawa

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. EDNRB2 regulates fate, migration, and maturation of hair cell precursors in regenerating avian auditory epithelium explants.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marie TakeuchiDepartment of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.ORCID 0009-0007-6098-045X
Mami MatsunagaDepartment of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.ORCID 0009-0005-6627-0817
Tomoko KitaDepartment of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0003-3457-0119
Koji NishimuraDepartment of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0003-0507-8184
Yosuke TonaDepartment of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0001-6868-8057
Koichi OmoriDepartment of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0003-3404-5461
Tatsuya KatsunoDepartment of Anatomy and Neurobiology, Center for Anatomical Studies, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0002-0395-4382
Takayuki NakagawaDepartment of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0002-6964-5638

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 20K09708MEXT | Japan Society for the Promotion of Science (JSPS) 22K16899MEXT | Japan Society for the Promotion of Science (JSPS) 23K08983
6 · The paper itself

Abstract

The mammalian cochlea loses its ability to regenerate hair cells (HCs) after birth. In contrast, in the avian auditory epithelium, the basilar papilla (BP), supporting cells (SCs) retain the capability for HC regeneration throughout life. Our previous study using single-cell RNA sequencing indicated a stepwise fate conversion of SCs to HCs via a precursor state, in which endothelin receptor type B2 (

Indexed as

Hair Cells, AuditoryReceptor, Endothelin BRegenerationAnimalsCell DifferentiationCell MovementChick EmbryoChickensEpitheliumSignal TransductionStem CellsReceptor, Endothelin Bfate determinationhair cellmigrationprecursorregeneration

Identifiers

PMID40627393
PMCPMC12280915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.