Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Sourabh SoniDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.ORCID 0000-0002-2323-1245
Soner YildizDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.ORCID 0000-0002-7235-6108
Emma Kaitlynn AllenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Hans PetersenChronic Obstructive Pulmonary Disease Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108.
Mark PeeplesCenter for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205.ORCID 0000-0002-4582-317X
Sara El ZahedDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.ORCID 0000-0002-0039-1780
Lorena RosasDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.
Vandana AnangDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.ORCID 0000-0003-0259-4773
Laura AntonescuDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.
Richard Seonghun NhoDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.ORCID 0000-0002-8023-5680
Ana Lucia MoraDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.ORCID 0000-0003-1653-8318
Jeffrey Craig HorowitzDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.ORCID 0000-0002-1505-2837
Mauricio RojasDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.
Rafael Andrés MedinaPathology Advanced Translational Research Unit, Department of Pathology and Laboratory Medicine Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-5013-6884
Paul Glyndwr ThomasDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0001-7955-0256
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.ORCID 0000-0002-6551-1827
Yohannes TesfaigziDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-3997-5839
Yohannes Afework MebratuDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.ORCID 0000-0002-5360-2158
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Resolution of Epithelial Cell Hyperplasia in AsthmaR01HL068111 · NHLBI · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI TESFAIGZI, YOHANNES · 2003 to 2021
$10.9M
Immunobiology of Influenza Virus-related Critical Illness in Young HostsR01AI154470 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI RANDOLPH, ADRIENNE G, THOMAS, PAUL G. · 2020 to 2024
$4.7M
Wood Smoke and Chronic Mucous HypersecretionR01HL140839 · NHLBI · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI TESFAIGZI, YOHANNES · 2018 to 2021
$2.8M
Influenza Modeling of Correlates of Protection for Optimal Immune Dynamics and Evolution.U01AI187057 · NIAID · EMORY UNIVERSITY · PI Rafael A. Medina Silva, Gene Brian Tan · 2025 to 2026
$2.3M
The role of Bik in the replication and severity of influenza A virusR01AI148180 · NIAID · OHIO STATE UNIVERSITY · PI MEBRATU, YOHANNES AFEWORK · 2021 to 2025
$2.1M
Hypoxia-induced aberrant lactate generation and shuttling serves as a direct signal to promote pro-fibrotic fibroblast phenotypesR01HL171164 · NHLBI · OHIO STATE UNIVERSITY · PI Jeffrey C Horowitz, Richard S. Nho · 2025 to 2026
$1.5M
HHS | National Institutes of Health (NIH) R01AI148180HHS | National Institutes of Health (NIH) R01AI154470HHS | National Institutes of Health (NIH) RO1HL068111 R01HL140839NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL068111NHLBI NIH HHS R01 HL140839NHLBI NIH HHS R01 HL171164NIAID NIH HHS 75N93021C00014NIAID NIH HHS 75N93021C00016NIAID NIH HHS R01 AI148180NIAID NIH HHS R01 AI154470NIAID NIH HHS U01 AI187057
6 · The paper itself
Abstract
Influenza A viruses (IAVs) pose a significant public health threat, with host factors playing a crucial role in disease severity. We investigated the role of Bcl-2-interacting killer (BIK) in IAV infection using cellular and mouse models, and influenza-infected human cohort. In airway epithelial cells (AECs), BIK deficiency impaired viral replication, while BIK restoration enhanced it. Conversely, airway-specific BIK overexpression in mice increased viral load, inflammation, and mortality, whereas BIK suppression conferred protection. Critically, a genetic variation (rs738276) in the
Indexed as
Apoptosis Regulatory ProteinsInfluenza, HumanMembrane ProteinsOrthomyxoviridae InfectionsProteasome Endopeptidase ComplexAnimalsEpithelial CellsHumansInfluenza A virusMiceMice, Inbred C57BLNucleocapsid ProteinsPolymorphism, Single NucleotideRisk FactorsRNA-Binding ProteinsViral Core ProteinsApoptosis Regulatory ProteinsMembrane ProteinsNP protein, Influenza A virusNucleocapsid ProteinsProteasome Endopeptidase ComplexRNA-Binding ProteinsViral Core ProteinsBeta 5BIKInfluenza A virusProteasomeSNP
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza. · full record | OpenQuestion