Evidence map›Paper›PMID 40627389›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Motilin stimulates food intake linked to gastric motility in

Jin Huang, Ayumi Watanabe, Moeko Kanaya, Ayano Gomi, Haruka Yokoyama, Hikari Ishii, Yusuke Nakamura, Morio Azuma, Norifumi Konno, Hiroyuki Kaiya and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jin HuangDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Sakuraku, Saitama 338-8570, Japan.ORCID 0000-0002-2607-4185
Ayumi WatanabeDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Sakuraku, Saitama 338-8570, Japan.
Moeko KanayaDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Sakuraku, Saitama 338-8570, Japan.ORCID 0000-0002-1856-8492
Ayano GomiDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Sakuraku, Saitama 338-8570, Japan.
Haruka YokoyamaDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Sakuraku, Saitama 338-8570, Japan.
Hikari IshiiDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Sakuraku, Saitama 338-8570, Japan.
Yusuke NakamuraDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Sakuraku, Saitama 338-8570, Japan.
Morio AzumaDivision of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan.
Norifumi KonnoDepartment of Biological Science, Graduate School of Science and Engineering, University of Toyama, Gofuku, Toyama 930-8555, Japan.
Hiroyuki KaiyaDivision of Drug Discovery, Grandsoul Research Institute for Immunology, Inc., Uda, Nara 633-2221, Japan.ORCID 0000-0001-7667-5344
Takafumi SakaiSaitama University, Sakuraku, Saitama 338-8570, Japan.ORCID 0000-0001-5929-4160
Ichiro SakataDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Sakuraku, Saitama 338-8570, Japan.ORCID 0000-0002-6067-0407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal-derived hormone motilin, a peptide belonging to the ghrelin family, induces strong gastric contractions and hunger sensations. However, whether motilin regulates food intake and its association with gastric motility remains unclear. Rodents are unsuitable for animal studies of motilin function, as both the motilin and motilin-receptor genes exist only as pseudogenes in their genomes. In this study, we investigated the role of motilin on food intake by simultaneously monitoring gastric contractions and their central mechanisms in the house musk shrew (

Indexed as

ConsciousnessEatingGastrointestinal MotilityMotilinShrewsAnimalsGhrelinMaleMyoelectric Complex, MigratingProto-Oncogene Proteins c-fosVagotomyGhrelinMotilinProto-Oncogene Proteins c-fosfood intakegastric motilitymotilinsuncus murinusvagus nerve

Identifiers

PMID40627389
PMCPMC12280924

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.