Evidence map›Paper›PMID 40627385›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The WWP1-JARID1B axis sustains acute myeloid leukemia chemoresistance.

Claudia Fierro, Sara Giovannini, Valeria Moriconi, Claudia Fiorilli, Emanuele Panatta, Valentina Frezza, Federica Corigliano, Rosalba Pecorari, Yanan Li, Ji Zhou and 10 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Claudia Fierro *Department of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0003-3227-1254
Sara Giovannini *Department of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0002-8916-476X
Valeria MoriconiDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0009-0002-0307-0680
Claudia FiorilliDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0009-0005-6442-7083
Emanuele PanattaDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0001-8723-9564
Valentina FrezzaDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0002-5286-0278
Federica CoriglianoDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.
Rosalba PecorariDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.
Yanan LiDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.
Ji ZhouDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0002-5365-5751
Vincenza Simona DelvecchioDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.
Artem SmirnovDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0002-1575-8725
Jose Manuel Garcia ManteigaCenter for Omics Sciences, Istituti di Ricovero e Cura a Carattere Scientifico, San Raffaele Scientific Institute, Milan 20132, Italy.ORCID 0000-0002-5481-040X
Andrea BrendolanLymphoid stromal cell biology Unit, Division of Experimental Oncology, Istituti di Ricovero e Cura a Carattere Scientifico, San Raffaele Scientific Institute, Milan 20132, Italy.
Jinping ZhangInstitutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, China.
Yufang ShiThe First Affiliated Hospital of Soochow University, Institutes for Translational Medicine, Soochow University, Suzhou 215000, China.
Ivano AmelioSystems Toxicology, Department of Biology, University of Konstanz, Konstanz 78464, Germany.
Eleonora CandiDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0001-8332-4825
Gerry MelinoDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0001-9428-5972
Francesca BernassolaDepartment of Experimental Medicine, Tor Vergata Oncoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0002-8883-8654

Funding

Fondazione AIRC per la ricerca sul cancro ETS (AIRC) IG 2019 - 23232MUR-PNRR M4C2I1.3 PE6 PE00000019
6 · The paper itself

Abstract

To uncover substrates mediating the oncogenic activity of WWP1 in acute myeloid leukemia (AML), we performed a proteomic analysis that identified the histone demethylase

Indexed as

Drug Resistance, NeoplasmJumonji Domain-Containing Histone DemethylasesLeukemia, Myeloid, AcuteRepressor ProteinsUbiquitin-Protein LigasesCell Line, TumorDNA DamageHistonesHumansNuclear ProteinsHistonesJumonji Domain-Containing Histone DemethylasesKDM5B protein, humanNuclear ProteinsRepressor ProteinsUbiquitin-Protein Ligasesacute myeloid leukemiaDNA repairprotein degradationprotein ubiquitination

Identifiers

PMID40627385
PMCPMC12280953

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.