Trial reportEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2025
Superficial Parasternal Intercostal Plane Block and Full Sternotomy; A Randomized Trial.
Trial report in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
New Truncal Nerve Blocks for Thoracoscopic Surgery and Open Heart Surgery.
Effect of Induction-Time Multimodal Fascial Plane Block on Postoperative Analgesia and Opioid Consumption in Patients Undergoing Isolated Coronary Artery Bypass Grafting: A Prospective Randomized Controlled Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectivesCardiac surgery via full sternotomy impacts postoperative lung function. We studied whether ultrasound-guided superficial parasternal intercostal plane block (SPIP) before surgical aortic valve replacement via full sternotomy would ameliorate postoperative lung function and filtration capacity.
methodsA total of 74 consecutive patients undergoing surgical aortic valve replacement were randomized to receive either or not additional SPIP. Pre- and postoperative lung function tests were compared among the patients. Venous and arterial blood samples were collected to calculate lung filtration (venous/arterial) of the inflammatory factors chemerin, chitinase-3-like protein 1 (YKL-40), resistin, and interleukin-6 (IL6) immediately before (T1), 1 hour after releasing aortic cross-clamp (T2), and on the following morning (T3) after surgery in 30 age- and sex-adjusted patients.
resultsPatients with SPIP were older as compared to those without (66.7 [10.7] vs 60.2 [13.4], years, respectively, P < 0.04). Neither other patient characteristics nor preoperative lung functions differed between the patient groups. Forced expiratory volume in 1 second (FEV), forced volume capacity (FVC), and relative FVC changes decreased less in patients treated with wound analgesia as compared to those without (P = 0.024, P = 0.042, and P = 0.042). Total oxycodone consumption (P = 0.634), YKL-40, and resistin did not differ between the groups. Arterial chemerin decreased and venous/arterial IL6 ratio increased in patients with SPIP as compared to those without (P = 0.024 versus P = 0.332, respectfully).
conclusionsSPIP before aortic valve surgery via full sternotomy impacts postoperative respiratory function and venous/arterial IL6 ratio. CLINICAL REGISTRATION NUMBER: The study was approved by the institutional review board (Ethical Committee of the Tampere University Hospital, Tampere, Finland, registration number R18011M) on March 8, 2018, and the study conforms to the ethical guidelines of the Declaration of Helsinki. The trial was registered as ClinicalTrials.gov ID NCT03704753 (EudraCT = 2017-004744-38).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.