Evidence map›Paper›PMID 40627335›Full record

ReviewStem cells translational medicine2025

The need for an organoid manufacturing, preservation, and distribution center.

Anthony Atala, John C Bischof, Christopher S Chen, John P Fisher, David L Hermanson, Charles L Howe, Walter C Low, Zhen Ma, David H McKenna, Sean P Palecek and 2 more

Abstract readReview
In one paragraph

Review in Stem cells translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Biomaterials in organoid research: current state and future directions.Frontiers in bioengineering and biotechnology · 2026
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anthony AtalaWake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC 27101, United States.
John C BischofAdvanced Technologies for the Preservation of Biological Systems, NSF ERC, University of Minnesota, Minneapolis, MN 55455, United States.
Christopher S ChenCellular Metamaterials, NSF ERC, Boston University, Boston, MA 02215, United States.
John P FisherFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, United States.
David L HermansonCell and Gene Therapy Applications, Bio-Techne, Minneapolis, MN 55413, United States.
Charles L HoweResearch Office of Core Shared Services, Mayo Clinic, Rochester, MN 55905, United States.
Walter C LowStem Cell Institute, University of Minnesota, University of Minnesota, Minneapolis, MN 55455, United States.
Zhen MaDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, United States.
David H McKennaMolecular and Cellular Therapeutics, University of Minnesota, St. Paul, MN 55108, United States.
Sean P PalecekCell Manufacturing Technologies, NSF ERC, University of Wisconsin, Madison, WI 53706, United States.
Johnna S TemenoffCell Manufacturing Technologies, NSF ERC, Georgia Institute of Technology, Atlanta, GA 30332, United States.
Brenda M OgleDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United States.ORCID 0000-0001-7613-7490

Funding

National Science Foundation 1647837National Science Foundation EEC 1648035National Science Foundation EEC 1941543
6 · The paper itself

Abstract

Organoids, which are tiny, lab-grown 3D structures that mimic some organizational and functional properties of human organs, are slowly transforming the face of systems and developmental biology, biomedical research, pharmaceutical testing, environmental toxin testing, and healthcare. Significant investments are essential for the mass production, preservation, and distribution of organoids, with the aim to accelerate innovation and progress across multiple fields-much like the investments made in cell and biologics manufacturing over the past 2 decades.

Indexed as

OrganoidsHumansbiomanufacturingcryopreservationdistributionorganoidstandardization

Identifiers

PMID40627335
PMCPMC12236065

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.