ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2025
Polyphenolic profile, hepatoprotective evaluation, and molecular docking study of three palm tree species (Family Arecaceae).
Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- ATR-FTIR Assessment of the Antioxidant and Anti-Inflammatory Effects of (-)-Epicatechin in MASLD.ACS omega · 2026Article
- Protective Effects of Mesembryanthemum Crystallinum Extract Against Cadmium-Induced Reproductive Oxidative Stress: Experimental and Docking Evidence for a Sustainable Therapeutic Strategy.Biological trace element research · 2026Article
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12 authors.
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Abstract
Arecaceae species are renowned in traditional medicine for treating inflammation and liver disorders. Herein, we aimed to identify the phenolic constituents and the hepatoprotective potential of the aqueous methanol extract (AME) of Aiphanes eggersii, Carpoxylon macrospermum, and Jubaeopsis caffra leaves, in a drug-induced liver injury in vivo model. The AMEs are considered safe until the maximum tested dose (5 g/kg). The two selected screening doses, 500 and 1000 mg/kg, displayed antioxidant activity with significant (P < 0.05) decline in the liver/body weight ratios (19.1-29.7%), liver enzymes (25.9-63.4%), and malondialdehyde (39.3-63.8%), while increasing reduced glutathione (2.1-3.2 folds) and superoxide dismutase (2.2-3.1 folds). Moreover, they demonstrated a significant anti-inflammatory effect (P < 0.05) with decline in NF-
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