ArticleEJNMMI physics2025
S-values for bone marrow dosimetry in preclinical radiopharmaceutical studies with rodents.
Article in EJNMMI physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDevelopment of novel radiopharmaceuticals involves dosimetry calculations to validate safety and aid with selection of those that should be translated into the clinical environment. Dosimetry is critical for limiting radiation damage to organs at risk. The bone marrow is a limiting organ in radiopharmaceutical therapies (RPTs) for metastatic prostate cancer, for example, but there is room for improvement of bone marrow dosimetry in preclinical studies. Bone marrow S-values for Lutetium-177 (
methodsS-values for
resultsThe phantoms simulated here differed from the OLINDA phantom in both organ mass and geometry for many tissues; S-value deviations from OLINDA were correlated with these differences, as reported in previous studies, and ranged from 2% for the kidney self-dose in the higher resolution (HR) phantom to 477% for S(skeleton←spleen) in the lower resolution (LR) phantom. S-values were simulated for the bone marrow in both phantoms; cross-dose values were greatest from the skeleton, brain, and lungs, while cross-doses from the simulated tumours were approximately constant at 3 × 10
conclusionUsing the MOBY digital mouse phantom, we simulated bone marrow S-values for
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