Evidence map›Paper›PMID 40627227›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Pain and lymphedema characteristics of women with breast cancer-related lymphedema with and without type 2 diabetes mellitus.

Esra Uzelpasaci, Aysel Ozge Kemer, Ozgu Inal Ozün, Aysegül Yaman

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Esra UzelpasaciDepartment of Cardiopulmonary Physiotherapy and Rehabilitation, Gülhane Faculty of Physiotherapy and Rehabilitation, University of Health Sciences, Ankara, Turkey. esra.uzelpasaci@sbu.edu.tr.
Aysel Ozge KemerGülhane Training and Research Hospital, Physical Therapy and Rehabilitation Unit, University of Health Sciences, Ankara, Turkey.
Ozgu Inal OzünDepartment of Neurologic Phsiotherapy and Rehabilitation, Gülhane Faculty of Physiotherapy and Rehabilitation, University of Health Sciences, Ankara, Turkey.
Aysegül YamanPhysical Medicine and Rehabilitation Hospital, Ankara Etlik City Hospital, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aimed to compare the pain and lymphedema characteristics of women with breast cancer-related lymphedema (BCRL) with and without type 2 diabetes mellitus (T2DM).

methodsA case-control study was conducted with 105 breast cancer survivors diagnosed with unilateral BCRL, divided into T2DM (n = 51) and non-T2DM (n = 54) groups. For pain characteristics, Visual Analog Scale (VAS) and Self-administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) were used. In addition, circumference measurement, the Lymphedema Life Impact Scale (LLIS), and Lymphedema Quality of Life Questionnaire (LYMQOL) were applied to determine the severity of lymphedema and its impact on quality of life. Statistical analysis was performed using t-tests, Mann-Whitney U tests, and Chi-square tests.

resultsT2DM patients exhibited significantly higher pain intensity (VAS) (p

conclusionT2DM significantly amplifies pain and worsens lymphedema-related outcomes in BCRL patients, underscoring the need for targeted, multidisciplinary interventions that address metabolic, physical, and psychosocial factors. Although lymphedema severity, duration, and volume were significantly higher in the T2DM group, these factors may have also contributed to the reduced functional status and quality of life outcomes independently of T2DM. Future research should explore the long-term relationship between T2DM, pain, and lymphedema to develop comprehensive care strategies for this population.

Indexed as

Breast Cancer LymphedemaBreast NeoplasmsDiabetes Mellitus, Type 2LymphedemaPainAdultAgedCancer SurvivorsCase-Control StudiesFemaleHumansMiddle AgedPain MeasurementQuality of LifeSeverity of Illness IndexSurveys and QuestionnairesDiabetes mellitusLymphedemaNeuropathic painQuality of life

Identifiers

PMID40627227

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.