ArticleJournal of neurology2025
Central nervous system involvement and mimickers in ANCA associated vasculitis.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Diagnosis and Treatment Pathway for Eosinophilic Granulomatosis with Polyangiitis in the Allergy Department.Diagnostics (Basel, Switzerland) · 2026Review
- Vasculitis syndromes: large vessel vasculitides and ANCA-associated vasculitides from a neuroradiologist's perspective.Japanese journal of radiology · 2026Review
- ANCA-Associated Vasculitis with Predominant Peripheral and Central Nervous System Involvement: A Case Report.Journal of inflammation research · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCentral nervous system (CNS) involvement is rare in ANCA-associated vasculitis (AAV). On the other hand, AAV patients may develop complications or other conditions that mimic CNS involvement. We aimed to present the clinical, laboratory and imaging features of our AAV patients with CNS involvement and conditions other than CNS involvement that caused neurologic symptoms.
methodWe surveyed the charts of 430 AAV patients in order to identify patients who were evaluated for neurologic symptoms suggesting CNS involvement. We extracted data on their demographics, AAV features, neurologic symptoms, final diagnoses after neurologic work-up, and their outcomes.
resultsOf 430 AAV patients, 61 patients (14%) (41 GPA, 11 MPA, 9 EGPA; 27 women, 34 men; mean age: 51.6 ± 15.4 years) with neurologic symptoms were identified. At the time of the occurrence of neurologic symptoms, all patients had active disease [median (IQR) BVAS=11.9 (7-15)]. The causes of neurologic symptoms were CNS involvement of AAV in 7 patients (meningeal involvement in 3, ischemic cerebrovascular accident in 2, intracranial hypertension in 1, and cerebral venous sinus thrombosis in 1), other AAV manifestations such as ocular, orbital and nasopharyngeal involvement in 30, and drug-related adverse events or comorbidities mimicking CNS involvement such as infections, atherosclerotic or thromboembolic events in 15 patients. Neurologic work-up did not lead to an underlying condition in 9.
conclusionCNS involvement was uncommon, observed in only 1.6% of patients. AAV manifestations other than CNS involvement, as well as complications like infections and cardiovascular disease may mimic CNS involvement in patients with AAV.
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