ArticleNeuroradiology2025
Isolated restricted diffusion in glioblastoma: incidence, progression, and survival impact '.
Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Basal ganglia glioblastoma with lung adenocarcinoma tumor-to-tumor metastasis and atypical early imaging presentation: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundGlioblastoma (GB) is the most malignant primary brain tumor. Isolated restricted diffusion (IRD) is restricted diffusion outside the confines of enhancing tumor with no corresponding enhancement on post contrast study. The aim of our study was to prospectively assess the incidence of IRD in GB patients, determine how often these foci proceed to contrast enhancement on follow up, and analyze the survival pattern of patients with IRD.
methodsIn a prospective pilot cohort study, consecutive adult patients (≥ 18 years old) suspected of having GB on initial MRI of brain, were included and screened for the presence of IRD. All images were independently analyzed by two experienced radiologists for inter-rater reliability. The survival pattern of patients with IRD was assessed with Cox-regression and Kaplan-Meier curve analysis.
resultsOf the 52 patients (median age- 63 years; male-63.5%) included, 21% (11 of 52) exhibited foci of IRD. Inter-rater agreement on the diagnosis of IRD foci was fair (kappa = 0.29) between the two readers. Among the 11 patients with IRD, only 7 (64%) showed enhancement in the IRD focus on imaging at a median follow up time of 110 days. The Kaplan Meier analysis revealed a significant decrease (p = 0.035) in the survival among patients with IRD focus.
conclusionIn conclusion, IRD foci were seen in 21% of patients with GB, with 64% of these demonstrating enhancement at the IRD focus on follow up imaging. A shorter survival was associated with IRD foci.
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