ArticleClinical cancer research : an official journal of the American Association for Cancer Research2025
Human Kallikrein 2: A Novel Lineage-Specific Surface Target in Prostate Cancer.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Development of XYD113 as a potent and highly selective GSPT1 degrader for cancer therapy.Acta pharmacologica Sinica · 2026Article
- Immunoediting and precision biomarkers in prostate cancer: The emerging role of liquid biopsy, immune contexture and HLA genotype (Review).International journal of oncology · 2026Review
- Evaluation of Tissue from Patients with Prostate Cancer Identifies B7-H3 as an Androgen-Regulated, Broadly Expressed, Combinatorial Therapeutic Target.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- The path forward for T cell engagers in patients with prostate cancer.Journal for immunotherapy of cancer · 2026Review
- Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review).International journal of oncology · 2026Review
- A Platform-Independent Binary Gene-Pair Signature Derived from CRPC-Enriched Single-Cell Transcriptomics for Predicting Recurrence-Free Survival in Prostate Cancer.Cancer management and research · 2026Article
- Drug Discovery Strategies for Kallikrein-Related Peptidases.International journal of molecular sciences · 2025Review
- Drug Targets in Prostate Cancer: An Appetite for KLK2-Mediated Destruction.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
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14 authors.
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Abstract
purposeTargeted therapies for metastatic prostate cancer are limited, highlighting the need for novel drug targets and mechanisms of action (MoA). Human kallikrein 2 (KLK2) is a prostate-specific antigen expressed across the prostate cancer disease continuum. However, it was not recognized as a therapeutic target for prostate cancer in the past due to limited evidence of its cell surface expression. In this study, we systematically characterized KLK2 expression in prostate cancer, confirmed its cell surface expression, and demonstrated the preclinical efficacy of three KLK2-targeting therapeutics with distinct MoA. EXPERIMENTAL
designThe KLK2 expression profile in different stages of prostate cancer and its cell surface expression were confirmed by IHC and multiplex immunofluorescent staining. The preclinical efficacy of three KLK2-targeting therapeutics was characterized using in vitro prostate cancer cell lines, patient-derived material, and in vivo xenograft mouse models.
resultsKLK2 was found to be robustly and homogeneously expressed in localized prostate cancer and metastatic hormone-sensitive prostate cancer, whereas some heterogeneity was observed in the visceral lesions of metastatic castration-resistant prostate cancer. KLK2 expression was more specific than that of other prostate cancer target antigens. Although KLK2 is traditionally described as a secreted protease, our results demonstrated its cell surface expression in both prostate cancer cell lines and patient-derived tumors. Notably, targeting KLK2 with three different MoAs, including bispecific T-cell redirector, targeted α-radioligand, and autologous chimeric antigen receptor T cells, showed potent in vitro activity and robust in vivo tumor control.
conclusionsOur study establishes KLK2 as a highly prostate-specific cell surface target. Targeting KLK2 with various MoAs represents novel therapeutic approaches for advanced prostate cancer. See related commentary by Blinka and Yu, p. 4393.
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