ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025
Fracture risks in patients aged 50 years and older with panhypopituitarism: a nationwide cohort study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Response to a letter to the editor on fracture risks in patients with arginine vasopressin deficiency: a nationwide matched cohort study (OSIN-D-26-00525).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Sex differences in clinical and metabolic outcomes of glucocorticoid replacement therapy in adrenal insufficiency.Pituitary · 2026Review
- Nationwide Big Data Studies of Endocrine Diseases Using the Korean National Health Information Database: Research Trends and Standardization of Operational Definitions.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- Adrenal Crisis Induced by Zoledronic Acid in Two Patients With Hypopituitarism: A Case Report and Literature Review.Case reports in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
This study investigated fracture risks in 3,877 older adults with panhypopituitarism compared with matched controls using Korean health insurance data. Findings showed higher risks of major osteoporotic, spine, and hip fractures in both men and women with panhypopituitarism compared to controls, with a more pronounced increase in risk among men. PURPOSE: Patients with hypopituitarism are known to have increased cardiovascular risk and mortality; however, data on fracture risk are limited. We aimed to identify gender- and site-specific fracture risks and factors associated with fractures in patients aged ≥ 50 years with panhypopituitarism, compared with age-, sex-, and index year-matched controls.
methodsUsing the Korea National Health Insurance Service (NHIS) Database, we identified 3,877 patients with panhypopituitarism aged ≥ 50 years and 1:10 age-, sex-, and index year-matched controls. Demographics comorbidities, and fracture outcomes, including major osteoporotic fractures (MOFs), vertebral fractures (VFs), non-vertebral fractures (non-VFs), and hip fractures (HFs), were obtained using the International Classification of Disease-10 codes and hospital records.
resultsThe mean ages of male and female panhypopituitary patients were 63.5 and 63.6 years, respectively. Male patients exhibited a significantly elevated risk of MOFs (hazard ratio [HR] = 2.16, 95% confidence interval [CI] = 1.87-2.48), VFs (HR = 2.13, 95% CI = 1.80-2.51), non-VFs (HR = 2.41, 95% CI = 1.94-3.00), and HFs (HR = 2.28, 95% CI = 1.59-3.27) compared to controls (all P < 0.001). Similarly, female patients demonstrated a significantly increased risk of MOFs (HR = 1.29, 95% CI = 1.16-1.42), VFs (HR = 1.45, 95% CI = 1.29-1.63), and HFs (HR = 1.68, 95% CI = 1.26-2.24) compared to controls (all P < 0.001), but not non-VFs. In addition to known risk factors like age, female sex, and fracture history, cerebrovascular disease, dementia, and low income were also associated with higher MOFs.
conclusionPatients with panhypopituitarism, particularly males, have a higher risk of fracture than matched controls. Comorbidities such as dementia and cerebrovascular disease may further increase the risk of fractures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.