Trial reportPsychopharmacology2026
Effects of methamphetamine on human effort task performance are unrelated to its subjective effects.
Trial report in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species.Molecular psychiatry · 2026Article
- Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs.Psychopharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
rationaleStimulant drugs increase objective indices of reward-related behavior, including willingness to expend effort for reward, and also produce feelings of well-being and positive mood. However, it is not known to what extent these different measures are related to each other.
objectivesThe present study was designed to assess the relationship between the behavioral measure of effort expenditure and positive subjective responses to methamphetamine (MA).
methods96 healthy adults completed the Effort Expenditure for Rewards Task (EEfRT) during two laboratory sessions after receiving 20 mg MA or placebo (PL) under double blind conditions. They also self-reported their mood states and drug effects.
resultsMA (vs. PL) increased willingness to complete a high effort/high reward option vs. a low effort/low reward option during the EEfRT (N = 96), and this effect was greater in participants with low effort at baseline. A subjective value modeling analysis (N = 91) showed that MA decreased sensitivity to the perceived cost of effort for the low baseline performance group only. MA also increased self-reported positive affect (euphoria; N = 94, liking the drug; N = 92) in the full sample, but this increase was unrelated to either baseline EEfRT performance or MA-induced EEfRT performance changes (N = 91).
conclusionsAs reported previously, MA increased choice of the high effort/high reward option, particularly in participants with low effort at baseline, who also showed drug-induced changes in effort sensitivity. These behavioral effects were not related to drug liking and drug-induced euphoria. These findings suggest that the effects of stimulants on reward-related behavior and mood are dissociable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.